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Invitrogen
CYLD Polyclonal Antibody
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CYLD Antibody (PA5-106325) in IHC (P)
Immunohistochemistry analysis of CYLD in mouse testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with CYLD polyclonal antibody (Product # PA5-106325) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-106325
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CYLD(Accession Q9NQC7), corresponding to amino acid residues V876-L926.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total CYLD.
靶标信息
CYLD is a 956 aa, cytoplasmic, deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family of proteins with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains, a proline rich region, a SH3 binding domain and a sequence homology to catalytic domain of UCH. CYLD is identified as a tumor suppressor protein affecting the JNK signaling pathway. CYLD is a negative regulator of TRAF2 and NF-kappa-B signaling pathway and is also known to have receptor-dependent role in regulating the I-kappa-B kinase pathway. It also has a deubiquitinating activity that is directed towards non-Lys-48-linked polyubiquitin chains and TRAP1 is a novel substrate for deubiquitination. Mutated CYLD is known to be associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cyld; cylindromatosis (turban tumor syndrome); Deubiquitinating enzyme CYLD; FLJ20180; FLJ31664; FLJ78684; probable ubiquitin carboxyl-terminal hydrolase CYLD; retinitis pigmentosa 1 homolog; Ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin specific peptidase like 2; Ubiquitin thioesterase CYLD; ubiquitin thiolesterase CYLD; Ubiquitin-specific-processing protease CYLD; unnamed protein product
基因别名: 2010013M14Rik; 2900009M21Rik; BRSS; C130039D01Rik; CDMT; CYLD; CYLD1; CYLDI; EAC; FTDALS8; HSPC057; KIAA0849; LRRGT00003; MFT; MFT1; mKIAA0849; Rp1; Rp1h; SBS; TEM; USPL2
UniProt ID: (Human) Q9NQC7, (Rat) Q66H62, (Mouse) Q80TQ2
Entrez Gene ID: (Human) 1540, (Rat) 312937, (Mouse) 74256
thiol-dependent ubiquitin-specific protease activity
protein binding
peptidase activity
cysteine-type peptidase activity
zinc ion binding
hydrolase activity
protein kinase binding
metal ion binding
Lys63-specific deubiquitinase activity
ubiquitinyl hydrolase activity, acting on linear ubiquitin
proline-rich region binding
Lys48-specific deubiquitinase activity
molecular_function
structural constituent of ribosome
thiol-dependent ubiquitinyl hydrolase activity
ribosomal protein
immune system process
proteolysis
I-kappaB kinase/NF-kappaB signaling
regulation of mitotic cell cycle
regulation of tumor necrosis factor-mediated signaling pathway
Wnt signaling pathway
protein deubiquitination
negative regulation of NF-kappaB transcription factor activity
negative regulation of type I interferon production
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
defense response to bacterium
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
innate immune response
regulation of B cell differentiation
positive regulation of T cell differentiation
negative regulation of JNK cascade
homeostasis of number of cells
regulation of inflammatory response
negative regulation of inflammatory response
positive regulation of T cell receptor signaling pathway
regulation of necroptotic process
necroptotic process
regulation of microtubule cytoskeleton organization
protein K63-linked deubiquitination
negative regulation of canonical Wnt signaling pathway
ripoptosome assembly involved in necroptotic process
negative regulation of NIK/NF-kappaB signaling
regulation of cilium assembly
negative regulation of p38MAPK cascade
positive regulation of cellular protein localization
protein linear deubiquitination
negative regulation of interleukin-18-mediated signaling pathway
positive regulation of extrinsic apoptotic signaling pathway
regulation of intrinsic apoptotic signaling pathway
cytoplasmic translation
ubiquitin-dependent protein catabolic process
biological_process
negative regulation of NF-kappaB import into nucleus
negative regulation of T cell differentiation
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