Invitrogen

CYP11A1 Recombinant Rabbit Monoclonal Antibody (PSH07-26)

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说明书
实验方案
问题与答案
技术支持
CYP11A1 Recombinant Rabbit Monoclonal Antibody (PSH07-26)

产品信息

MA562408

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:2,000
-

免疫组化（石蜡） (IHC (P))

1:500
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

PSH07-26

抗原

Recombinant protein within human CYP11A1 aa 1-350.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_3703594

产品详细信息

Positive Control: HepG2 cell lysate, Caco-2 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, Mouse testis tissue lysate, Mouse ovary tissue lysate, Mouse brain tissue lysate, Rat testis tissue lysate, Rat ovary tissue lysate.

Tissue Specificity: Tissue enriched (adrenal).

Subcellular Location: Mitochondrion inner membrane.

Sequence Similarities: 75% Mouse/Rat.

Predicted band size: 60 kDa.

靶标信息

CYP11A1, also known as cytochrome P450C11A1, cytochrome P450scc and cytochrome P450, subfamily XIA, is an enzyme that catalyzes the first step of steroid biosynthesis under the modulation of cAMP signal. CYP11A1 in steroidogenic cells converts cholesterol to pregnenolone, which is determined by hormonal control of cholesterol availability. Expression of the CYP11A1 gene is controlled by the transcription factor SF-1, and the upstream SF-1 binding site in the CYP11A1 gene is required for hormonal stimulation. c-Jun and SF-1 may act synergistically to activate CYP11A1 gene expression. Both Forskolin and 8-Br-cAMPS elevate CYP11A1 mRNA levels in the interstitial cell monolayer, which has a fully functional adenylate cyclase.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: cholesterol 20-22 desmolase; Cholesterol desmolase; cholesterol monooxygenase (side-chain cleaving); cholesterol side chain cleavage; cholesterol side-chain cleavage cytochrome P450; Cholesterol side-chain cleavage enzyme, mitochondrial; CYPXIA1; cytochrome P450 11a cholesterol side chain cleavage; Cytochrome P450 11A1; cytochrome P450 family 11 subfamily A polypeptide 1; cytochrome P450 side-chain cleavage enzyme; cytochrome P450 subfamily 11A; Cytochrome P450(scc); cytochrome P450, 11a, cholesterol side-chain cleavage; cytochrome P450, family 11, subfamily A, polypeptide 1; cytochrome P450, subfamily XIA (cholesterol side chain cleavage); cytochrome P450C11A1; P450(scc); steroid 20-22-lyase

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基因别名: cscc; CYP11A; Cyp11a-1; CYP11A1; CYPXIA1; D9Ertd411e; P450SCC; Scc

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UniProt ID: (Human) P05108, (Rat) P14137, (Mouse) Q9QZ82

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Entrez Gene ID: (Human) 1583, (Rat) 29680, (Mouse) 13070

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功能
iron ion binding cholesterol monooxygenase (side-chain-cleaving) activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen heme binding cholesterol binding monooxygenase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen metal ion binding
参与通路
organic acid metabolic process steroid biosynthetic process C21-steroid hormone biosynthetic process progesterone biosynthetic process estrogen biosynthetic process response to nutrient mating behavior cholesterol metabolic process male gonad development response to salt stress response to organic substance response to ionizing radiation response to gamma radiation Schwann cell differentiation response to organic cyclic compound response to insecticide biphenyl metabolic process dibenzo-p-dioxin metabolic process phenol-containing compound metabolic process phthalate metabolic process cerebellum development hippocampus development response to vitamin E Leydig cell differentiation response to L-ascorbic acid response to genistein response to gonadotropin response to drug response to hydrogen peroxide response to amino acid response to alkaloid response to peptide hormone response to estrogen cellular response to fibroblast growth factor stimulus response to antibiotic response to cadmium ion response to steroid hormone response to corticosterone response to cAMP oxidation-reduction process granulosa cell differentiation maternal process involved in female pregnancy response to fungicide testosterone biosynthetic process cellular response to lipopolysaccharide cellular response to antibiotic cellular response to cadmium ion cellular response to cAMP cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to gonadotropin stimulus cellular response to follicle-stimulating hormone stimulus cellular response to peptide hormone stimulus cellular response to transforming growth factor beta stimulus glucocorticoid biosynthetic process sterol metabolic process cortisol metabolic process vitamin D metabolic process secondary metabolite biosynthetic process lipid metabolic process steroid metabolic process
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