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Abnova
CYP11B1 Polyclonal Antibody, MaxPab™
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00001584-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CYP11B1 (AAH96285.1, 1 a.a. approximately 574 a.a) full-length human protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MALRAKAEVC MAVPWLSLQR AQALGTRAAR VPRTVLPFEA MPRRPGNRWL RLLQIWREQG YEDLHLEVHQ TFQELGPIFR SRHSASFGRW GRSAARAGLW RCQGRGWCRA NPSSLQRGQD SEALKYDLGG AGMVCVMLPE DVEKLQQVDS LHPHRMSLEP WVAYRQHRGH KCGVFLLNVA DRGNSSPPFP GGIHGAPTHS GCRNGPEWRF NRLRLNPEVL SPNAVQRFLP MVDAVARDFS QALKKKVLQN ARGSLTLDVQ PSIFHYTIEA SNLALFGERL GLVGHSPSSA SLNFLHALEV MFKSTVQLMF MPRSLSRWTS PKVWKEHFEA WDCIFQYGDN CIQKIYQELA FSRPQQYTSI VAELLLNAEL SPDAIKANSM ELTAGSVDTT VFPLLMTLFE LARNPNVQQA LRQESLAAAA SISEHPQKAT TELPLLRAAL KETLRLYPVG LFLERVASSD LVLQNYHIPA GTLVRVFLYS LGRNPALFPR PERYNPQRWL DIRGSGRNFY HVPFGFGMRQ CLGRRLAEAE MLLLLHHVLK HLQVETLTQE DIKMVYSFIL RPSMFPLLTF RAIN
靶标信息
The steroid 11beta-hydroxylase gene, also designated Cyp11b-1, is a marker for the functional differentiation of cells in the zonae fasciculata reticularis. The deduced protein CYP11B1 consists of 466 amino acids containing a secretory signal, epidermal growth factor-like repeats, and a proteolytically inactive cathepsin B-related sequence. A related protein, human aldosterone synthase (CYP11B2), is involved in substrate recognition and conversion, with a functionally significant residue 112 in the N-terminal region of human CYP11B2. The inherited disorder glucocorticoid-remediable aldosteronism is caused by a chimeric gene duplication between the CYP11B1 and CYP11B2 genes. This disorder is characterized by hyperaldosteronism and high levels of 18-hydroxycortisol and 18-oxocortisol, which are under ACTH control.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CYP11B1; CYPXIB1; Cytochrome P-450c11; Cytochrome P450 11B1, mitochondrial; Cytochrome P450C11; DKFZp686B05283; FLJ36771; P450C 11; Steroid 11-beta-hydroxylase, CYP11B1
基因别名: CYP11B1; S11BH
Entrez Gene ID: (Human) 1584
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