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Invitrogen
CYP11B1 Polyclonal Antibody
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CYP11B1 Antibody (PA5-95041) in WB
Western blot analysis of CYP11B1/CYP11B2 in Lane 1: HeLa whole cell lysate (40 µg), Lane 2: U87 whole cell lysate (40 µg), Lane 3: MM231 whole cell lysate (40 µg), Lane 4: PANC whole cell lysate (40 µg), Lane 5: MM453 whole cell lysate (40 µg), Lane 6: HeLa whole cell lysate (40 µg), Lane 7: SMMC whole cell lysate (40 µg). Samples were incubated with CYP11B1/CYP11B2 polyclonal antibody (Product # PA5-95041).
产品信息
PA5-95041
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human CYP11B1 (436-450aa RNFYHVPFGFGMRQC).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: HELA whole cell, U87 whole cell, MM231 whole cell, PANC whole cell, MM453 whole cell, HELA whole cell, SMMC whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
The steroid 11beta-hydroxylase gene, also designated Cyp11b-1, is a marker for the functional differentiation of cells in the zonae fasciculata reticularis. The deduced protein CYP11B1 consists of 466 amino acids containing a secretory signal, epidermal growth factor-like repeats, and a proteolytically inactive cathepsin B-related sequence. A related protein, human aldosterone synthase (CYP11B2), is involved in substrate recognition and conversion, with a functionally significant residue 112 in the N-terminal region of human CYP11B2. The inherited disorder glucocorticoid-remediable aldosteronism is caused by a chimeric gene duplication between the CYP11B1 and CYP11B2 genes. This disorder is characterized by hyperaldosteronism and high levels of 18-hydroxycortisol and 18-oxocortisol, which are under ACTH control.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CYP11B1; CYPXIB1; Cytochrome P-450c11; Cytochrome P450 11B1, mitochondrial; cytochrome p450 XIB1; cytochrome P450, family 11, subfamily B, polypeptide 1; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1; Cytochrome P450C11; DKFZp686B05283; FLJ36771; P450C 11; steroid 11-beta-hydroxylase; Steroid 11-beta-hydroxylase, CYP11B1; steroid 11-beta-monooxygenase
基因别名: CPN1; CYP11B; CYP11B1; FHI; P450C11; S11BH
UniProt ID: (Human) P15538
Entrez Gene ID: (Human) 1584
C21-steroid hormone biosynthetic process
glucocorticoid biosynthetic process
immune response
cholesterol metabolic process
regulation of blood pressure
sterol metabolic process
aldosterone biosynthetic process
cellular response to hormone stimulus
cortisol biosynthetic process
cellular response to potassium ion
glucose homeostasis
secondary metabolite biosynthetic process
oxidation-reduction process
cellular response to peptide hormone stimulus
