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CYP11B1/CYP11B2 Polyclonal Antibody

查看其他3个CYP11B1/CYP11B2抗体

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说明书
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说明书
实验方案
问题与答案
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说明书
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问题与答案
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CYP11B1/CYP11B2 Polyclonal Antibody

产品信息

PA5-143908

应用
建议稀释比
已发表文章

免疫印迹 (WB)

0.25-0.5 µg/mL
-

流式细胞分析 (Flow)

1-3 µg/10x^6 cells
-

酶联免疫吸附实验 (ELISA)

0.1-0.5 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

E.coli-derived human CYP11B1/C11B2/CYP11B2 recombinant protein (Position: M1-P491).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 4mg trehalose

内含物

0.01mg sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_3075122

产品详细信息

Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Positive Control - WB: rat kidney tissue, mouse kidney tissue. Flow: 293T cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

靶标信息

The steroid 11beta-hydroxylase gene, also designated Cyp11b-1, is a marker for the functional differentiation of cells in the zonae fasciculata reticularis. The deduced protein CYP11B1 consists of 466 amino acids containing a secretory signal, epidermal growth factor-like repeats, and a proteolytically inactive cathepsin B-related sequence. A related protein, human aldosterone synthase (CYP11B2), is involved in substrate recognition and conversion, with a functionally significant residue 112 in the N-terminal region of human CYP11B2. The inherited disorder glucocorticoid-remediable aldosteronism is caused by a chimeric gene duplication between the CYP11B1 and CYP11B2 genes. This disorder is characterized by hyperaldosteronism and high levels of 18-hydroxycortisol and 18-oxocortisol, which are under ACTH control.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: ALDOS; Aldosterone synthase; Aldosterone-synthesizing enzyme; Corticosterone 18-monooxygenase, CYP11B2; CYP11B1; CYPXIB1; CYPXIB2; CYPXIB3; Cytochrome P-450Aldo; Cytochrome P-450c11; Cytochrome P-450C18; Cytochrome P450 11B1, mitochondrial; Cytochrome P450 11B2, mitochondrial; cytochrome P450 11B3, mitochondrial; Cytochrome P450 subfamily XIB polypeptide 2 (aldosterone synthase); cytochrome p450 XIB1; cytochrome P450(11 beta)-DS; cytochrome P450, family 11, subfamily B, polypeptide 1; cytochrome P450, family 11, subfamily B, polypeptide 2; cytochrome P450, subfamily 11B, polypeptide 1; cytochrome P450, subfamily 11B, polypeptide 2; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2; Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase); Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase); cytochrome P450-Aldo-1; cytochrome P450-Aldo-2; Cytochrome P450C11; mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2; P450(11 beta)-DS; P450-Aldo-1; P450-Aldo-2; P450C11; steroid 11-beta-hydroxylase; Steroid 11-beta-hydroxylase, CYP11B1; Steroid 11-beta-hydroxylase, CYP11B2; steroid 11-beta-monooxygenase; steroid 11-beta/18-hydroxylase; Steroid 18-hydroxylase; steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo; steroid-11-beta-hydroxylase

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基因别名: AA389061; ALDOS; Cp11ba; Cp45as; CPN1; CPN2; CYP11B; Cyp11b-1; Cyp11b-2; CYP11B1; CYP11B2; Cyp11b3; CYP11BL; CYPXIB2; FHI; P-450C18; P450aldo; P450C11; P450C18; RATCP11BA; RNCP45AS; S11BH

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UniProt ID: (Human) P15538, (Human) P19099, (Mouse) P15539

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Entrez Gene ID: (Human) 1584, (Human) 1585, (Mouse) 110115, (Rat) 500892, (Mouse) 13072, (Rat) 24294

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功能
steroid 11-beta-monooxygenase activity iron ion binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen heme binding corticosterone 18-monooxygenase activity steroid hydroxylase activity steroid binding monooxygenase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen metal ion binding
参与通路
regulation of blood volume by renal aldosterone C21-steroid hormone biosynthetic process glucocorticoid biosynthetic process aldosterone biosynthetic process potassium ion homeostasis sodium ion homeostasis oxidation-reduction process regulation of systemic arterial blood pressure by circulatory renin-angiotensin steroid biosynthetic process regulation of blood pressure cortisol biosynthetic process drinking behavior positive regulation of blood pressure ion homeostasis response to nutrient response to salt stress cellular response to nutrient response to insulin cellular response to hormone stimulus cellular response to potassium ion response to drug response to peptide hormone cellular response to potassium ion starvation cellular response to mechanical stimulus cellular response to peptide hormone stimulus renal water homeostasis mineralocorticoid biosynthetic process cholesterol metabolic process sterol metabolic process secondary metabolite biosynthetic process immune response glucose homeostasis steroid metabolic process glucocorticoid metabolic process dibenzo-p-dioxin metabolic process adenosine metabolic process cellular response to interferon-gamma response to dexamethasone
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