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Invitrogen
CYP2C8 Polyclonal Antibody
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Product Details
PA5-101311
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CYP2C8(Accession P10632), corresponding to amino acid residues E250-E300.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Cytochrome P450 2C8.
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CYPIIC8; cytochrome P-450 1; cytochrome P-450 S-mephenytoin 4-hydroxylase; Cytochrome P450 2C8; Cytochrome P450 form 1; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; cytochrome P450, family 2, subfamily C, polypeptide 8; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8; flavoprotein-linked monooxygenase; IIC2; microsomal monooxygenase; P450 form 1; P450 IIC2; P450 MP-12/MP-20; S-mephenytoin 4-hydroxylase; unnamed protein product; xenobiotic monooxygenase
Gene Aliases: CPC8; CYP2C8; CYP2C8DM; CYPIIC8; MP-12/MP-20
UniProt ID: (Human) P10632
Entrez Gene ID: (Human) 1558
monooxygenase activity
iron ion binding
protein binding
arachidonic acid epoxygenase activity
retinoic acid 4-hydroxylase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
heme binding
caffeine oxidase activity
metal ion binding
estrogen 16-alpha-hydroxylase activity
lipid hydroxylation
organic acid metabolic process
lipid metabolic process
terpenoid metabolic process
xenobiotic metabolic process
steroid metabolic process
estrogen metabolic process
arachidonic acid metabolic process
epoxygenase P450 pathway
monocarboxylic acid metabolic process
xenobiotic catabolic process
retinol metabolic process
retinoic acid metabolic process
long-chain fatty acid biosynthetic process
icosanoid biosynthetic process
oxidative demethylation
omega-hydroxylase P450 pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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