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Rockland
CaBP7 Polyclonal Antibody
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CaBP7 Antibody (600-401-AA1) in ICC/IF
Immunocytochemistry of CaBP7 antibody. Tissue: HeLa cells. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: CaBP7 antibody at 4 µg/mL for 1 hr at RT. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: CaBP7 is a membrane protein. Staining: CaBP7 as precipitated blue signal with pink nuclear counterstain.
产品信息
600-401-AA1
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Anti-CaBP7 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide near the N-terminus of human CaBP7.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Calcium binding proteins (CaBP) play a crucial role in the calcium-mediated cellular signal transduction pathway in the central nervous system. The CaBP family shares much similarity with CaM I (calmodulin), and it has been shown that CaBP proteins can substitute functionally for, and possibly augment the function of, CaM I. CaBP7 (Calcium-binding protein 7), contains two EF-hand domains for calcium binding and shares 70% homology with CaBP8 and 50% homology with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. CaBP7 and 8 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca2+-sensing by these family members.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CaBP7; Calcium-binding protein 7; calcium-binding protein CaBP7; calneuron 2; Calneuron II; Calneuron-2; calneuron-II
基因别名: CABP7; CALN2; rCaBP7
UniProt ID: (Human) Q86V35, (Mouse) Q91ZM8, (Rat) Q66H96
Entrez Gene ID: (Human) 164633, (Mouse) 192650, (Rat) 360970
