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Alomone Labs, LTD

CaV1.2 (CACNA1C) Polyclonal Antibody

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CaV1.2 (CACNA1C) Polyclonal Antibody

产品信息

ACC-003-GP200UL

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:200
-

Multiplex Immunohistochemistry (mIHC)

Assay-dependent
-

免疫组化（石蜡） (IHC (P))

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Rat, Xenopus

宿主/亚型

Guinea pig / IgG

分类

Polyclonal

类型

Antibody

抗原

(C)TTKINMDDLQPSENEDKS, corresponding to amino acid residues 848-865 of rat CaV1.2, Intracellular loop between domains II and III
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.8 mg/mL

规格

160 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

靶标信息

CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by CACNA1C binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: brain class C; CACH3; CACN4; CACNA 1D; CACNA1C intronic transcript 2; CACNA1C intronic transcript 2 (non-protein coding); CACNL1A2; calcium channel voltage-dependent alpha1c subunit; calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; calcium channel, voltage-dependent, alpha 1C subunit; calcium channel, voltage-dependent, L type, alpha 1C subunit; CaV1.2; DHP receptor; DHPR, alpha-1 subunit; L-type calcium channel alpha-1 subunit; long-NT; LTCC; MBC; MELC-CC; MGC120730; Mouse brain class C; neuronal voltage-gated calcium channel alpha 1C subunit; Rat brain class C; RBC; skeletal muscle-specific calcium channel; unnamed protein product; voltage-dependent L-type Ca2+ channel alpha 1 subunit; Voltage-dependent L-type calcium channel subunit alpha-1C; Voltage-gated calcium channel subunit alpha Cav1.2

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基因别名: CACH2; CACN2; CACNA1C; CACNA1C-IT2; CACNL1A1; CaV1.2; CCHL1A1; D930026N18Rik; LQT8; MBC; MELC-CC; NEDHLSS; RATIVS302; TS; TS. LQT8

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UniProt ID: (Human) Q13936, (Mouse) Q01815, (Rat) P22002

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Entrez Gene ID: (Human) 775, (Mouse) 12288, (Rat) 24239

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功能
ion channel activity voltage-gated calcium channel activity calcium channel activity protein binding calmodulin binding high voltage-gated calcium channel activity metal ion binding alpha-actinin binding voltage-gated calcium channel activity involved in cardiac muscle cell action potential voltage-gated calcium channel activity involved in AV node cell action potential voltage-gated ion channel activity enzyme binding protein domain specific binding ion channel binding protein phosphatase 2A binding voltage-gated ion channel
参与通路
immune system development ion transport calcium ion transport muscle contraction positive regulation of cytosolic calcium ion concentration heart development regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ion transmembrane transport embryonic forelimb morphogenesis camera-type eye development positive regulation of adenylate cyclase activity positive regulation of muscle contraction transmembrane transport calcium ion transport into cytosol cardiac conduction calcium ion transmembrane transport via high voltage-gated calcium channel calcium ion transmembrane transport cardiac muscle cell action potential involved in contraction membrane depolarization during cardiac muscle cell action potential membrane depolarization during AV node cell action potential cell communication by electrical coupling involved in cardiac conduction regulation of heart rate by cardiac conduction calcium ion import across plasma membrane regulation of ventricular cardiac muscle cell action potential membrane depolarization during atrial cardiac muscle cell action potential transport cellular calcium ion homeostasis smooth muscle contraction chemical synaptic transmission adult walking behavior regulation of blood pressure visual learning calcium ion regulated exocytosis regulation of vasoconstriction insulin secretion growth hormone secretion regulation of ion transmembrane transport glucose homeostasis regulation of organ growth smooth muscle contraction involved in micturition calcium ion import membrane depolarization during action potential
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