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Invitrogen
CaV1.3 Polyclonal Antibody
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CaV1.3 Antibody (PA5-78902) in WB
Western blot analysis of CaV1.3 in Lane 1: rat brain tissue lysate, Lane 2: mouse brain tissue lysate using 50 µg (reducing conditions) per well. Electrophoresis was performed on 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours and protein was transferred to a nitrocellulose membrane at 150mA for 50-90 minutes. Sample was blocked with 5% Non-fat Milk/TBS for 1.5 hours at room temperature, incubated with CaV1.3 polyclonal antibody (Product # PA5-78902) at a dilution of 0.5 µg/mL (overnight at 4°C), followed by go... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-78902
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human CaV1.3 recombinant protein (Position: M1-I180).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Rat Brain Tissue, Mouse Brain Tissue. Flow: U-87 cell.
靶标信息
CACNA1D is also known as PASNA, SANDD or Cav1. 3. Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: brain class D; CACNA 1D; calcium channel alpha-1 subunit; Calcium channel, L type, alpha-1 polypeptide isoform 2; Calcium channel, L type, alpha-1 polypeptide, isoform 2; CaV1.3alpha1; RBD; voltage-dependent calcium channel subunit alpha1D; Voltage-dependent L-type calcium channel subunit alpha-1D; voltage-gated calcium channel pore forming subunit CaV1.3alpha1 IVS3-IVS4 extracellular linker; Voltage-gated calcium channel subunit alpha Cav1.3
基因别名: 8430418G19Rik; C79217; CACH3; CACN4; CACNA1D; CACNL1A2; Cav1.3; Cchl1a; CCHL1A2; D-LTCC
UniProt ID: (Mouse) Q99246
Entrez Gene ID: (Mouse) 12289, (Rat) 29716
voltage-gated calcium channel activity
protein binding
high voltage-gated calcium channel activity
PDZ domain binding
ankyrin binding
metal ion binding
alpha-actinin binding
voltage-gated calcium channel activity involved in cardiac muscle cell action potential
voltage-gated calcium channel activity involved SA node cell action potential
voltage-gated ion channel
calcium ion transport
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
heart development
aging
sensory perception of sound
memory
calcium-mediated signaling
positive regulation of CREB transcription factor activity
regulation of ion transmembrane transport
regulation of calcium ion transport
positive regulation of calcium ion transport
regulation of atrial cardiac muscle cell membrane repolarization
calcium ion import
calcium ion transmembrane transport
divalent metal ion transport
membrane depolarization during action potential
membrane depolarization during cardiac muscle cell action potential
membrane depolarization during SA node cell action potential
membrane repolarization during SA node cell action potential
regulation of heart rate by cardiac conduction
regulation of potassium ion transmembrane transporter activity
regulation of potassium ion transmembrane transport
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