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Invitrogen
CaV1.3 Polyclonal Antibody
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FIGURE: 1 / 2
CaV1.3 Antibody (PA5-78902) in WB
Western blot analysis of CaV1.3 in Lane 1: rat brain tissue lysate, Lane 2: mouse brain tissue lysate using 50 µg (reducing conditions) per well. Electrophoresis was performed on 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours and protein was transferred to a nitrocellulose membrane at 150mA for 50-90 minutes. Sample was blocked with 5% Non-fat Milk/TBS for 1.5 hours at room temperature, incubated with CaV1.3 polyclonal antibody (Product # PA5-78902) at a dilution of 0.5 µg/mL (overnight at 4°C), followed by go... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-78902
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human CaV1.3 recombinant protein (Position: M1-I180).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Rat Brain Tissue, Mouse Brain Tissue. Flow: U-87 cell.
Target Information
CACNA1D is also known as PASNA, SANDD or Cav1. 3. Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha 1 E; brain class D; CACNA 1D; calcium channel alpha-1 subunit; calcium channel, L type, alpha-1 polypeptide; calcium channel, neuroendocrine/brain-type, alpha 1 subunit; calcium channel, voltage-dependent, L type, alpha 1D subunit; CaV1.3alpha1; ion channel; RBD; unnamed protein product; variant CaCh3 (delta IVS3 delta IVS4); variant CaCh3 (delta IVS3 delta part IVS4); variant CaCh3b (delta part IVS4); voltage-dependent calcium channel subunit alpha1D; voltage-gated calcium channel alpha 1 subunit; voltage-gated calcium channel alpha subunit Cav1.3; voltage-gated calcium channel pore forming subunit CaV1.3alpha1 IVS3-IVS4 extracellular linker; voltage-gated calcium channel subunit alpha Cav1.3
Gene Aliases: 8430418G19Rik; CACH3; CACN4; CACNL1A2; Cav1.3; Cchl1a; CCHL1A2; D-LTCC; PASNA; SANDD
UniProt ID: (Human) Q01668, (Mouse) Q99246
Entrez Gene ID: (Human) 776, (Rat) 29716, (Mouse) 12289
ion channel activity
voltage-gated calcium channel activity
calcium channel activity
protein binding
cytoskeletal protein binding
high voltage-gated calcium channel activity
ankyrin binding
alpha-actinin binding
voltage-gated calcium channel activity involved in cardiac muscle cell action potential
voltage-gated calcium channel activity involved SA node cell action potential
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
PDZ domain binding
voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
ion transport
calcium ion transport
cell communication
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
heart development
sensory perception of sound
memory
regulation of metal ion transport
calcium-mediated signaling
optic nerve development
signaling
metal ion transport
response to estradiol
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of adenylate cyclase activity
neurological system process
regulation of calcium ion transport
positive regulation of calcium ion transport
transmembrane transport
regulation of atrial cardiac muscle cell membrane repolarization
calcium ion import
calcium ion transmembrane transport
cardiac muscle cell action potential involved in contraction
membrane depolarization during cardiac muscle cell action potential
membrane depolarization during SA node cell action potential
regulation of heart rate by cardiac conduction
calcium ion import across plasma membrane
regulation of presynaptic cytosolic calcium ion concentration
regulation of potassium ion transmembrane transport
regulation of intracellular signal transduction
positive regulation of secretion by cell
regulation of cation transmembrane transport
positive regulation of membrane depolarization
cellular response to beta-amyloid
positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
muscle contraction
positive regulation of transport
cardiac conduction
positive regulation of presynaptic cytosolic calcium concentration
induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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