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Calcineurin A Polyclonal Antibody

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Calcineurin A Polyclonal Antibody

产品信息

PA1-12404

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫组化 (IHC)

Assay-dependent
-
产品规格

种属反应

Bovine, Human, Mouse, Rat

宿主/亚型

Sheep / IgG

分类

Polyclonal

类型

Antibody

抗原

Purified peptide conjugated to KLH (a.a. 481-494)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Ammonium sulfate precipitation

保存液

PBS

内含物

0.08% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2169654

产品详细信息

Peptide sequence: NH2-Arg-Met-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro-Ser-Asp-Ala-C00H

靶标信息

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Calcineurin A alpha; Calcineurin A1; calcineurin catalytic subunit; Calcineurin subunit A alpha; CalcineurinA; Calmodulin-dependent calcineurin A subunit alpha isoform; CALNA 1; CAM-PRP catalytic subunit; CCN 1; CNA alpha; PP2B alpha 1; PP2BA alpha; PP2CB; protein phosphatase; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha); Protein phosphatase 3 catalytic subunit alpha; protein phosphatase 3 catalytic subunit alpha isozyme; protein phosphatase 3, catalytic subunit, alpha isoform; protein phosphatase-2Ba; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; unnamed protein product

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基因别名: 2900074D19Rik; ACCIID; CALN; CALNA; CALNA1; CCN1; CN; CNA; CNA1; DEE91; IECEE; IECEE1; PPP2B; PPP3CA

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UniProt ID: (Bovine) P48452, (Human) Q08209, (Mouse) P63328, (Rat) P63329

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Entrez Gene ID: (Bovine) 286852, (Human) 5530, (Mouse) 19055, (Rat) 24674

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功能
protein binding calmodulin binding calmodulin-dependent protein phosphatase activity metal ion binding phosphoprotein phosphatase activity protein serine/threonine phosphatase activity calcium ion binding hydrolase activity enzyme binding protein dimerization activity ATPase binding calcium-dependent protein serine/threonine phosphatase activity drug binding protein heterodimerization activity protein phosphatase
参与通路
protein dephosphorylation dephosphorylation response to calcium ion G1/S transition of mitotic cell cycle protein import into nucleus calcium ion transport epidermis development positive regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of gene expression transition between fast and slow fiber cardiac muscle hypertrophy in response to stress calcium-mediated signaling negative regulation of signaling keratinocyte differentiation positive regulation of cell migration calcineurin-NFAT signaling cascade multicellular organismal response to stress wound healing positive regulation of activated T cell proliferation T cell activation proteasome-mediated ubiquitin-dependent protein catabolic process skeletal muscle tissue regeneration positive regulation of osteoblast differentiation positive regulation of osteoclast differentiation positive regulation of cell adhesion positive regulation of endocytosis positive regulation of transcription from RNA polymerase II promoter positive regulation of saliva secretion skeletal muscle fiber development dendrite morphogenesis negative regulation of dendrite morphogenesis modulation of synaptic transmission excitatory postsynaptic potential regulation of cell proliferation involved in kidney morphogenesis peptidyl-serine dephosphorylation renal sodium ion absorption positive regulation of calcineurin-NFAT signaling cascade positive regulation of glomerulus development renal filtration calcineurin-mediated signaling postsynaptic modulation of chemical synaptic transmission negative regulation of angiotensin-activated signaling pathway positive regulation of angiotensin-activated signaling pathway positive regulation of calcium ion-dependent exocytosis of neurotransmitter positive regulation of cardiac muscle hypertrophy in response to stress positive regulation of connective tissue replacement positive regulation of calcium ion import across plasma membrane negative regulation of calcium ion import across plasma membrane negative regulation of chromatin binding cellular response to drug negative regulation of insulin secretion positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NFAT protein import into nucleus cellular response to glucose stimulus response to amphetamine negative regulation of calcium ion-dependent exocytosis
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