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Fabgennix

Calcitonin Polyclonal Antibody

View all (23) Calcitonin antibodies

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Calcitonin Polyclonal Antibody

Product Details

CLTN-101AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 30-80 on human Calcitonin protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Calcitonin is a 32 amino acid peptide which can be demonstrated in C cells of the normal and hyperplastic thyroid. Staining for calcitonin may be used for the identification of a spectrum of C cell proliferative abnormalities ranging from C cell hyperplasia to invasive tumors. Staining for calcitonin in medullary carcinoma of the thyroid produces a fine granular pattern in the cytoplasm. Amyloid deposits within the tumor may also exhibit varying degrees of calcitonin activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Alpha CGRP; Alpha type CGRP; alpha-CGRP; alpha-type calcitonin gene-related peptide; alpha-type CGRP; calcitonin; calcitonin 1; calcitonin gene related peptide 1; calcitonin gene related protein; calcitonin gene-related peptide I; calcitonin precursor; calcitonin/calcitonin-related polypeptide, alpha; CGRP-I; katacalcin; katacalcin (KC); neuropeptide; alpha-CGRP; procalcitonin; unnamed protein product

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Gene Aliases: CA; Cal1; CAL6; Calc; CALC1; calcitonin; CGRP; CGRP-1; CGRP-alpha; CGRP-I; CGRP1; CT; Ctn; KC; PCT; RATCAL6

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UniProt ID: (Human) P01258, (Mouse) P70160, (Rat) P01256

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Entrez Gene ID: (Human) 796, (Mouse) 12310, (Rat) 24241

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Function(s)
receptor binding hormone activity protein binding calcitonin receptor binding identical protein binding macromolecular complex binding receptor agonist activity neuropeptide hormone activity
Process(es)
endothelial cell proliferation vasculature development neurological system process involved in regulation of systemic arterial blood pressure vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure regulation of heart rate G-protein coupled receptor internalization monocyte chemotaxis protein phosphorylation cellular calcium ion homeostasis inflammatory response leukocyte cell-cell adhesion adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway embryo implantation feeding behavior response to heat negative regulation of calcium ion transport into cytosol negative regulation of ossification receptor internalization negative regulation of neurological system process activation of protein kinase activity positive regulation of interleukin-1 alpha production positive regulation of interleukin-8 production vasodilation endothelial cell migration positive regulation of macrophage differentiation negative regulation of osteoclast differentiation negative regulation of blood pressure positive regulation of ossification negative regulation of bone resorption negative regulation of transcription, DNA-templated negative regulation of smooth muscle contraction sperm capacitation response to pain detection of temperature stimulus involved in sensory perception of pain regulation of cytosolic calcium ion concentration calcitonin family receptor signaling pathway amylin receptor 1 signaling pathway amylin receptor 2 signaling pathway cellular response to nerve growth factor stimulus calcitonin gene-related peptide receptor signaling pathway innate immune response antimicrobial humoral immune response mediated by antimicrobial peptide cellular response to tumor necrosis factor response to yeast cell-cell signaling regulation of blood pressure antibacterial humoral response antifungal humoral response defense response to Gram-negative bacterium defense response to Gram-positive bacterium
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