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Alomone Labs, LTD
Calcitonin Receptor (extracellular) Polyclonal Antibody
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Calcitonin Receptor (extracellular) Antibody (ACR-053-200UL) in ICC/IF
Expression of CALCR in rat PC12 cells - Cell surface detection of CALCR in intact living rat pheochromocytoma (PC12) cells. A, C. Extracellular staining of cells using Anti-Calcitonin Receptor (extracellular) Antibody , (#ACR-053), (1:50). B, D. Merged images of A and C, each with its respective live view of the cells.
产品信息
ACR-053-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)HLVEVVPNGDLVRRD, corresponding to amino acid residues 201-215 of rat CALCR, 1st extracellular loop
偶联物
形式
Lyophilized
浓度
0.85 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
The Calcitonin Receptor inhibits bone resorption. This receptor is expressed during development and is involved in morphogenesis. Three alternatively spliced Calcitonin Receptor isoforms have been identified. In addition to binding calcitonin, the Calcitonin Receptor can complex with RAMP3 (receptor activity modifying protein) to bind amylin, which regulates pancreatic islet function and is involved in Type II diabetes. The Calcitonin Receptor has been reported in artery, blood, bone, brain, kidney, lung, placenta, prostate, skeletal muscle, and thyroid. ESTs have been isolated from bone, embryo, kidney, and melanocyte/uterus/fetal heart libraries.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C1A/C1B; Calcitonin receptor; COPT1; CT receptor; CT-R; hCTR1
基因别名: Calcr; Clr
UniProt ID: (Rat) P32214, (Mouse) Q60755
Entrez Gene ID: (Rat) 116506, (Mouse) 12311
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
activation of phospholipase C activity
positive regulation of cytosolic calcium ion concentration
protein transport
negative regulation of ossification
osteoclast differentiation
positive regulation of cAMP biosynthetic process
receptor internalization
regulation of mRNA stability
regulation of bone resorption
positive regulation of adenylate cyclase activity
response to glucocorticoid
protein localization to plasma membrane
signal transduction
cell surface receptor signaling pathway
