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Rockland
Calmodulin Monoclonal Antibody (6D4)
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产品信息
200-301-P25
产品规格
种属反应
Chicken,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
6D4
抗原
Calmodulin antibody was produced in mice by repeated immunizations with a preparation of purified calmodulin from Dictyostelium discoideum conjugated to KLH.
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
1.2% sodium acetate with 2mg BSA
内含物
0.01% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Calmodulin is a small, highly conserved calcium binding protein found in all eukaryotic cells. With the capacity to bind up to four calcium ions, this 17 kDa protein acts as an important intracellular receptor for regulatory calcium signals. As it binds calcium, calmodulin undergoes conformational changes which can increase its affinity for target proteins. It acts both directly, through interaction with key target enzymes, and indirectly, via specific kinases. Studies have found that calmodulin participates in the regulation of several biological processes including energy and biosynthetic metabolism, cell motility, exocytosis, cytoskeletal assembly, and intracellular modulation of both cAMP and calcium concentrations. Calmodulin is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin contains 149 amino acids and has 4 calcium-binding domains. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CALM 1; Calmodulin; Calmodulin 1 (phosphorylase kinase, delta); calmodulin 2 (phosphorylase kinase, delta); Calmodulin III; Calmodulin-1; Calmodulin-2; Calmodulin-3; calmodulin-like protein; calmodulin-like protein (neoCaM); CaM; CAMI; DD312; Neo-calmodulin; NeoCaM
基因别名: CALM; Calm1; Calm2; Calm3; CAM; Cam1; Cam2; Cam3; Camb; Camc; CaMI; CaMII; CaMIII; RCJMB04_24e7; RNCAMIII
UniProt ID: (Chicken) P05419, (Chicken) P62149, (Rat) P0DP29
Entrez Gene ID: (Chicken) 396523, (Chicken) 395855, (Rat) 24242, (Rat) 50663, (Rat) 24244
calcium ion binding
enzyme regulator activity
protein C-terminus binding
myosin binding
CH domain binding
disordered domain specific binding
calcium channel regulator activity
protein binding
adenylate cyclase binding
protein kinase binding
protein domain specific binding
nitric-oxide synthase regulator activity
titin binding
type 3 metabotropic glutamate receptor binding
thioesterase binding
N-terminal myristoylation domain binding
phospholipase binding
phosphatidylinositol 3-kinase binding
ion channel binding
protein N-terminus binding
calcium-dependent protein binding
nitric-oxide synthase binding
protein phosphatase activator activity
calmodulin-related
microtubule cytoskeleton organization
calcium-mediated signaling
regulation of catalytic activity
G2/M transition of mitotic cell cycle
response to amphetamine
regulation of heart rate
detection of calcium ion
activation of adenylate cyclase activity
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
substantia nigra development
positive regulation of cyclic nucleotide metabolic process
regulation of cytokinesis
positive regulation of phosphoprotein phosphatase activity
positive regulation of protein dephosphorylation
positive regulation of DNA binding
positive regulation of nitric-oxide synthase activity
positive regulation of cyclic-nucleotide phosphodiesterase activity
response to calcium ion
regulation of cardiac muscle contraction
regulation of ryanodine-sensitive calcium-release channel activity
positive regulation of ryanodine-sensitive calcium-release channel activity
regulation of store-operated calcium channel activity
regulation of high voltage-gated calcium channel activity
