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Invitrogen
Carbamazepine Recombinant Mouse Monoclonal Antibody (4E5)
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Carbamazepine Antibody (MA566597) in SDS-PAGE
SDS-PAGE characterization of Carbamazepine under reducing conditions. Lane M: Protein marker (kDa); Lane CMZ: Purified Carbamazepine Recombinant Monoclonal (Product # MA566597). Carbamazepine showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-620.
产品信息
MA566597
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
4E5
抗原
Conjugate of CMZ hapten and KLH.
偶联物
形式
Liquid
浓度
5.2 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Carbamazepine is an anticonvulsant medication primarily used in the treatment of epilepsy and neuropathic pain. It functions by stabilizing inactive sodium channels in the brain, thereby reducing neuronal excitability. The drug is metabolized in the liver, and its active metabolite, carbamazepine-10,11-epoxide, contributes to its therapeutic effects. Carbamazepine is known for its enzyme-inducing properties, which can affect the metabolism of other drugs. Biosimilar formulations of carbamazepine, such as Taver® by MEDOCHEMIE, have been compared to the innovator product, Tegretol® by NOVARTIS, in terms of concentration over dose ratio, indicating potential differences in efficacy and safety profiles. Despite being considered bioequivalent in single-dose studies, these formulations may not maintain equivalence in a steady-state patient population. The development of photoswitchable carbamazepine analogs aims to reduce systemic side effects by allowing non-invasive neuroinhibition. This highlights the ongoing efforts to improve the safety and efficacy of carbamazepine and its biosimilars.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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