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Invitrogen
Carbonic Anhydrase VA/VB Monoclonal Antibody (487908)
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Carbonic Anhydrase VA/VB Antibody (MA5-24199) in IHC (P)
Immunohistochemical analysis of Carbonic Anhydrase VA/VB in immersion fixed paraffin-embedded sections of human liver. Samples were incubated in Carbonic Anhydrase VA/VB monoclonal antibody (Product # MA5-24199) using a dilution of 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic. Tissue was ... View More
产品信息
MA5-24199
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
487908
抗原
E. coli-derived recombinant human Carbonic Anhydrase VA/VB (CA5A/5B) Ala40-Ser305
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In Western blots, no cross-reactivity with recombinant human CA1, 4, or CA6-14 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
Carbonic anhydrases (CAs) are members of a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. CAs are involved in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric juice. They show extensive diversity in distribution and in their subcellular localization. The human CA5A gene encodes for the CA V protein which is expressed in the mitochondrial matrix in liver tissues, but can also be detected in many other tissues. In ureagenesis, the CA V protein may be involved in providing bicarbonate to carbamoyl phosphate synthetase. CA5B belongs a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. This protein is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. The protein has a wider tissue distribution than CA VA, which is restricted to the liver.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CA-VA; CA-VB; Carbonate dehydratase VA; Carbonate dehydratase VB; Carbonic anhydrase 5A, mitochondrial; Carbonic anhydrase 5B, mitochondrial; carbonic anhydrase V, mitochondrial; Carbonic anhydrase VA; carbonic anhydrase VA, mitochondrial; Carbonic anhydrase VB; carbonic anhydrase VB, mitochondrial; carbonic dehydratase
基因别名: CA-VB; CA5; CA5A; CA5AD; CA5B; CAV; CAVA; GS1-21A4.1
UniProt ID: (Human) P35218, (Human) Q9Y2D0
Entrez Gene ID: (Human) 763, (Human) 11238
