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Invitrogen
Carboxypeptidase A1/A2/B Recombinant Rabbit Monoclonal Antibody (11A12)
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Carboxypeptidase A1/A2/B Antibody (MA573085) in IHC (P)
Immunohistochemistry analysis of Carboxypeptidase A1/A2/B on paraffin-embedded Human Pancreas tissue. Antigen retrieval by boiling in sodium citrate buffer (pH 6.0) for 15 min. Samples were incubated with Carboxypeptidase A1/A2/B Recombinant Monoclonal (Product # MA573085) using a dilution at 1:200 overnight at 4°C. Followed by DAB staining.
产品信息
MA573085
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
11A12
抗原
KLH conjugated synthetic peptide derived from human Carboxypeptidase A1.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.575 mg/mL
规格
57.5 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Carboxypeptidases are pancreatic proteases that digest proteins by cleaving amino acids from the carboxyl (C-terminal) end of peptide chains, with Carboxypeptidase A1 (CPA1), A2 (CPA2), and B (CPB) playing central roles in protein metabolism. CPA1, encoded by the CPA1 gene, is a zinc-dependent metalloenzyme that preferentially removes aromatic or branched-chain amino acids; it is synthesized in the pancreas as the inactive zymogen proCPA1 and activated by trypsin in the small intestine. CPA2, encoded by CPA2, is also a zinc-dependent metalloenzyme produced as an inactive proenzyme and activated by intestinal proteases; while it shares significant homology with CPA1, it differs in substrate specificity and regulation, removing aromatic or aliphatic amino acids from peptide C-termini. In contrast, CPB, encoded by CPB1, has distinct substrate specificity, primarily cleaving basic amino acids such as arginine and lysine from the C-terminus of peptides; like CPA1 and CPA2, it is synthesized in the pancreas as an inactive zymogen and activated by trypsin in the small intestine, where it contributes to the final stages of protein digestion and broader physiological regulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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