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Immunogen sequence: QKQAQTERKS GKRQTEREKK KKILAERRKV LAIDHLNEDQ LREKAKELWQ SIYNLEAEKF DLQEKFKQQK YEINVLRNRI NDNQKVSKTR GKAKVTGRWK
Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Cardiac Troponin T is important in proper muscle function and myofibril formation. In the human heart, four cTnT isoforms are expressed in a developmentally regulated manner. Cardiac Troponin T expression in the human heart is affected by heart failure. Mutations within the Cardiac Troponin T protein have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for the Cardiac Troponin T gene undergo alternative splicing that results in many tissue-specific isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cardiac muscle troponin T; cardiac TnT; cardiac troponin T2; cTnT; MGC3889; TnTc; Troponin T cardiac; Troponin T, cardiac muscle; Troponin T2; troponin T2, cardiac
基因别名: cTnT; Ctt; CTTG; RATCTTG; Tnnt2; Tnnt3; Tnt
UniProt ID: (Rat) P50753, (Mouse) P50752
Entrez Gene ID: (Rat) 24837, (Mouse) 21956
分子生物学功能: actin binding motor protein