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Invitrogen
Caspase 1 p20 Polyclonal Antibody
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Caspase 1 p20 Antibody (PA5-78915) in WB
Western blot analysis of Caspase 1 p20 using Caspase 1 p20 Polyclonal Antibody (Product # PA5-78915). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel)/90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 µg of sample under reducing conditions. Lane 1: rat thymus tissue lysates. Lane 2: rat C6 whole cell lysates. Lane 3: mouse thymus tissue lysates. After electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA for 50-90 minutes. Blocked the membrane with 5% n... View More
产品信息
PA5-78915
产品规格
种属反应
Mouse,
Rat
已发表种属
C. elegans,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the N-terminus of mouse CASP1 (137-157aa LEKAQKLWKENPSEIYPIMNT).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat thymus tissue, rat C6 whole cell, mouse thymus tissue.
靶标信息
Caspase-1 (CASP1) is a thiol protease that cleaves IL-1 beta between Asp and Ala. This cleavage causes the release of the mature cytokine which is involved in a variety of inflammatory processes. CASP1 is important for defense against pathogen. It cleaves and activates sterol regulatory element binding proteins (SREBPs). CASP1 also promotes apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, CASP1 controls antiviral immunity through the cleavage of CGAS and renders it inactive.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CASP-1; Caspase-1; ICE; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL-1BC; interleukin 1 beta-converting enzyme; interleukin 1, beta, convertase; Interleukin 1beta converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45
基因别名: Casp1; ICE; Il1bc
UniProt ID: (Mouse) P29452
Entrez Gene ID: (Mouse) 12362, (Rat) 25166
response to hypoxia
microglial cell activation
proteolysis
apoptotic process
myoblast fusion
memory
response to bacterium
regulation of autophagy
response to organic cyclic compound
protein processing
response to lipopolysaccharide
interleukin-1 beta production
response to ATP
response to drug
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of circadian sleep/wake cycle, non-REM sleep
positive regulation of cytokine secretion
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
regulation of inflammatory response
mitochondrial depolarization
membrane hyperpolarization
pyroptosis
cellular response to organic substance
programmed necrotic cell death
toxin transport
midgut development
response to toxic substance
lung development
cellular response to mechanical stimulus
execution phase of apoptosis
