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In Western blot applications, this antibody detects a band at ~43kDa.
A suggested positive control is HL60 cell lysate.
PA5-19949 can be used with blocking peptide PEP-0074.
The immunogen is located within amino acids 80 - 130 of Caspase-13.
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 beta Converting Enzyme) and caspase-13. Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: apoptosis-related cysteine protease; apoptotic cysteine protease Mih1/TX; CASP-11; CASP-13; CASP-4; CASP13; caspase 11; caspase 4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; Caspase-11; Caspase-13; Caspase-4; ERICE; Evolutionary related interleukin-1-beta-converting enzyme; ICE and Ced-3 homolog 2; ICE(rel)-II; ICH-2; MGC137679; Mih1; protease ICH-2; Protease ICH-3; Protease TX
基因别名: CASP-11; CASP-4; Casp11; CASP13; CASP4; Caspl; ICE(rel)II; ICEREL-II; ICH-2; ich-3; ICH2; Ich3; Mih1; Mih1/TX; TX
UniProt ID: (Bovine) Q5E9C1, (Human) P49662, (Mouse) P70343
Entrez Gene ID: (Bovine) 338039, (Human) 837, (Rat) 114555, (Mouse) 12363
分子生物学功能:
protease