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Invitrogen
Caspase 3 p17 Polyclonal Antibody
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Caspase 3 p17 Antibody (PA5-78921) in IHC (P)
Immunohistochemistry analysis of Caspase 3 p17 on paraffin-embedded rat intestine tissue. Antigen retrieval was performed using citrate buffer (pH6, epitope retrieval solution) for 20 mins. Sample was blocked using 10% goat serum, incubated with Caspase 3 p17 polyclonal antibody (Product# PA5-78921) with a dilution of 1 µg/mL (overnight at 4°C), and followed by biotinylated goat anti-rabbit IgG (30 minutes ... View More
产品信息
PA5-78921
产品规格
种属反应
Mouse,
Rat
已发表种属
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the N-terminus of mouse Caspase-3 (P17) (67-81aa TDVDAANLRETFMGL).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Rat Heart Tissue, Rat Liver Tissue, Rat Thymus Tissue, Rat Spleen Tissue, mouse thymus tissue, mouse spleen tissue, mouse lung tissue, mouse brain tissue, mouse testis tissue. IHC: rat intestine tissue.
靶标信息
CASP3 (Caspase3 Apoptosis-Related Cysteine Protease), also known as YAMA, CPP32 or APOPAIN, is a caspase protein that interacts with caspase 8 and caspase 9. It is encoded by the CASP3 gene. The CASP3 protein is a member of the cysteine-aspartic acid protease (caspase) family. Tiso et al. (1996) used radiation hybrid mapping to localize the CPP32 gene to human chromosome 4q33-q35.1. Fernandes-Alnemri et al. (1994) found that overexpression of CPP32 in insect cells induced apoptosis. Coexpression of the 2 CPP32 subunits in insect cells also resulted in apoptosis. Tewari et al. (1995) showed that purified human ICE cleaved the Yama proenzyme into a proteolytically active form and that activated Yama cleaved PARP into the 85-kD apoptotic form.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Apopain; CASP-3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); Caspase-3; Cleaved Caspase 3; CPP-32; CPP32beta; Cysteine protease CPP32; IRP; LICE; Protein Yama; SCA-1; SREBP cleavage activity 1; yama protein
基因别名: A830040C14Rik; AC-3; Apopain; CASP-3; Casp3; Caspase-3; CC3; CPP-32; CPP32; Lice; mldy; SCA-1; Yama
UniProt ID: (Mouse) P70677, (Rat) P55213
Entrez Gene ID: (Mouse) 12367, (Rat) 25402
protease binding
aspartic-type endopeptidase activity
cysteine-type endopeptidase activity
cyclin-dependent protein serine/threonine kinase inhibitor activity
death receptor binding
protein binding
peptidase activity
cysteine-type peptidase activity
phospholipase A2 activator activity
hydrolase activity
protein complex binding
cysteine-type endopeptidase activity involved in apoptotic process
cysteine-type endopeptidase activity involved in execution phase of apoptosis
protease
B cell homeostasis
proteolysis
apoptotic process
cellular response to DNA damage stimulus
heart development
sensory perception of sound
learning or memory
response to UV
response to wounding
response to glucose
protein processing
neuron differentiation
keratinocyte differentiation
erythrocyte differentiation
negative regulation of B cell proliferation
glial cell apoptotic process
intracellular signal transduction
response to hydrogen peroxide
T cell homeostasis
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of catalytic activity
positive regulation of neuron apoptotic process
cell fate commitment
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cell cycle
negative regulation of activated T cell proliferation
neurotrophin TRK receptor signaling pathway
neuron apoptotic process
cellular response to organic substance
execution phase of apoptosis
response to hypoxia
release of cytochrome c from mitochondria
extrinsic apoptotic signaling pathway via death domain receptors
intrinsic apoptotic signaling pathway in response to oxidative stress
response to organic substance
response to metal ion
response to X-ray
response to organic cyclic compound
hippocampus development
response to cobalt ion
response to estradiol
response to lipopolysaccharide
response to nicotine
wound healing
response to drug
response to amino acid
response to antibiotic
response to glucocorticoid
cellular response to organic cyclic compound
extrinsic apoptotic signaling pathway in absence of ligand
regulation of apoptotic DNA fragmentation
