Hamburger Menu Button
Thermo Fisher Scientific Logo
登录
没有账号?建立账号 注册
  • 产品
    • 抗体
    • 引物合成
    • GeneArt Gene Synthesis Instant Designer
    • TaqMan Assay and Array Search
    • PCR 设备和耗材
    • 色谱柱和纯化柱
    • 实验室离心机
    • 分子生物学试剂和试剂盒
    • 实验室塑料耗材及用品
    • 查看所有产品分类
  • 应用和技术
    • 色谱
    • 细胞转染和培养
    • 实时荧光定量PCR
    • 质谱
    • 实验室塑料耗材及用品
    • 电子显微镜
    • 蛋白质生物学
    • PCR
    • RNAi
    • 环境
    • 查看所有应用和技术
  • 服务
    • 定制服务
    • 企业级实验室信息化服务
    • 金融&租赁服务
    • 仪器服务
    • OEM和商业供应
    • 培训服务
    • 360° CDMO 和 CRO 服务
    • CDMO 服务
    • 临床试验 CRO 服务
    • Unity Lab Services
    • 查看所有帮助和支持
  • 帮助和支持
    • 学习中心
    • 联系我们
    • 更改国家或地区
    • 查看所有帮助和支持
  • 热门产品
    • TaqMan Real-Time PCR Assays
      TaqMan 实时荧光定量 PCR 试剂盒
    • Antibodies
      抗体
    • Oligos, Primers & Probes
      寡核苷酸、引物、探针
    • GeneArt Gene Synthesis
      GeneArt 基因合成
    • Cell Culture Plastics
      细胞培养耗材
  • Who We Serve
    • 抗体治疗解决方案
    • 细胞与基因治疗解决方案
    • 学术科研
    • 工业与应用
  • 联系我们
  • 货号直购
  • 订单查询
  • 查找文件&证书
Thermo Fisher Scientific Logo

Search

搜索全部或下列指定分类
Search button
          • 联系我们
          • 货号直购
          • 登录
            登录
            没有账号?建立账号 注册
            • 我的账号
            • 订单
            • 账单及发票查询
            • 定制产品及项目
          • Primary Antibodies ›
          • beta Catenin Antibodies

          NeoBiotechnologies

          Catenin, beta (p120) Recombinant Rabbit Monoclonal Antibody (CTNNB1, 2030R)

          查看其他128个beta Catenin抗体

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

          说明书
          证书
          实验方案
          问题与答案
          技术支持
          说明书
          证书
          实验方案
          问题与答案
          技术支持
          说明书
          证书
          实验方案
          问题与答案
          技术支持

          Cite Catenin, beta (p120) Recombinant Rabbit Monoclonal Antibody (CTNNB1, 2030R)

          Additional Information:
          {{banner.description}}
          {{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
          • 抗体检测数据 (7)
          Catenin, beta (p120) Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          Catenin, beta (p120) Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          图: 1 / 7

          {{ $ctrl.currentElement.advancedVerification.fullName }}
          {{ $ctrl.currentElement.advancedVerification.text }}

          Catenin, beta (p120) Antibody (1499-RBM10-P1) in ICC/IF

          Immunocytochemistry/Immunofluorescence analysis of PFA fixed HeLa cells using Catenin, beta (p120) Recombinant Monoclonal Antibody (Product # 1499-RBM10-P1) followed by goat anti-Mouse IgG-CF488 (Green). The nuclear counterstain is Reddot (Red). {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
          查看产品

          {{$ctrl.videoDesc}}

          {{$ctrl.videoLongDesc}}

          Catenin, beta (p120) Antibody in Immunocytochemistry (ICC/IF)
          Catenin, beta (p120) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Catenin, beta (p120) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Catenin, beta (p120) Antibody in Western Blot (WB)
          Catenin, beta (p120) Antibody in Flow Cytometry (Flow)
          Catenin, beta (p120) Antibody in Peptide array (ARRAY)
          Catenin, beta (p120) Antibody in SDS-PAGE (SDS-PAGE)
          Catenin, beta (p120) Recombinant Rabbit Monoclonal Antibody (CTNNB1, 2030R)

          产品信息

          1499-RBM10-P1

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1-2 µg/mL
          -

          免疫组化(石蜡) (IHC (P))

          1-2 µg/mL
          -

          免疫细胞化学 (ICC/IF)

          1-2 µg/mL
          -

          流式细胞分析 (Flow)

          1-2 µg/10^6 cells
          -

          肽阵列 (Array)

          Assay-dependent
          -
          产品规格

          种属反应

          Human

          宿主/亚型

          Rabbit / IgG

          Expression System

          HEK293 cells

          分类

          Recombinant Monoclonal

          类型

          Antibody

          克隆号

          CTNNB1, 2030R

          抗原

          Recombinant full-length human beta-catenin protein
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          200 µg/mL

          纯化类型

          Protein A

          保存液

          PBS, pH 7.4, with 0.05% BSA

          内含物

          0.05% sodium azide

          保存条件

          4°C

          运输条件

          Ambient (domestic); Wet ice (international)

          产品详细信息

          Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.

          靶标信息

          Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. In the nucleus, beta-catenin serves to co activate a family of Lef/Tcf transcription factors that stimulate transcription of target genes including those encoding cyclin D and c-myc that promote cell proliferation. The influence on cell proliferation is the molecular basis for the role of beta-catenin in tumorgenesis, specifically, solid tumors of the breast, colon, liver, lung, gastric, prostate, and skin.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

          您是否在文献中引用过该产品?请点击下方按钮邮件告知我们。
          引用该产品

          生物信息学

          蛋白别名: Bcatenin; beta 1 88kDa; Beta-catenin; Betacatenin; C20orf33; Cadherin associated protein; catenin; catenin (cadherin-associated protein), beta 1, 88kDa; Catenin b 1; Catenin b1; Catenin beta-1; Catenin beta1; Catenin β 1; Catenin β1; CTNB1; dJ633O20.1; DKFZp686D02253; FLJ25606; FLJ37923; NAP; NYD-SP19; OTTHUMP00000209289; P14L; PP8304; RP5-1118M15.1; unnamed protein product; β catenin; βcatenin

          查看更多 收起

          基因别名: armadillo; CTNNB; CTNNB1; EVR7; MRD19; NEDSDV; OK/SW-cl.35; PRO2286

          查看更多 收起

          UniProt ID: (Human) P35222

          查看更多 收起

          Entrez Gene ID: (Human) 1499

          查看更多 收起

          功能
          transcription cofactor binding transcription corepressor binding chromatin binding transcription coactivator activity receptor binding protein binding ligand-dependent nuclear receptor binding enzyme binding kinase binding protein kinase binding phosphatase binding protein phosphatase binding estrogen receptor binding ubiquitin protein ligase binding ion channel binding alpha-catenin binding cadherin binding SMAD binding RNA polymerase II sequence-specific DNA binding transcription factor binding I-SMAD binding disordered domain specific binding DNA-binding transcription factor binding histone methyltransferase binding
          参与通路
          negative regulation of transcription from RNA polymerase II promoter MAPK cascade protein polyubiquitination embryonic axis specification cell morphogenesis skeletal system development patterning of blood vessels vasculogenesis osteoblast differentiation branching involved in ureteric bud morphogenesis in utero embryonic development gastrulation with mouth forming second endoderm formation cell fate specification endodermal cell fate commitment neuron migration kidney development epithelial to mesenchymal transition neural plate development tissue homeostasis vasculature development positive regulation of neuroblast proliferation positive regulation of mesenchymal cell proliferation chondrocyte differentiation lens morphogenesis in camera-type eye outflow tract morphogenesis regulation of secondary heart field cardioblast proliferation metanephros morphogenesis negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter cell adhesion cell-matrix adhesion epidermal growth factor receptor signaling pathway chemical synaptic transmission ectoderm development nervous system development glial cell fate determination neuroblast proliferation heart development protein localization cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation fibroblast growth factor receptor signaling pathway response to xenobiotic stimulus anterior/posterior axis specification dorsal/ventral axis specification dorsal/ventral pattern formation proximal/distal pattern formation mesenchymal cell proliferation gene expression regulation of gene expression positive regulation of gene expression negative regulation of gene expression regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition positive regulation of heparan sulfate proteoglycan biosynthetic process Wnt signaling pathway morphogenesis of embryonic epithelium negative regulation of angiogenesis stem cell population maintenance layer formation in cerebral cortex hypothalamus development central nervous system vasculogenesis hair cycle process hemopoiesis cell differentiation neuron differentiation T cell differentiation osteoclast differentiation lung development male genitalia development epithelial cell differentiation regulation of epithelial cell differentiation positive regulation of epithelial cell differentiation forebrain development midbrain development hindbrain development regulation of centriole-centriole cohesion pancreas development hair follicle morphogenesis regulation of protein ubiquitination regulation of myelination positive regulation of telomere maintenance via telomerase negative regulation of chondrocyte differentiation response to estradiol positive regulation of transcription elongation from RNA polymerase II promoter T cell differentiation in thymus negative regulation of protein sumoylation positive regulation of homotypic cell-cell adhesion adherens junction organization adherens junction assembly protein localization to cell surface embryonic heart tube development genitalia morphogenesis embryonic forelimb morphogenesis embryonic hindlimb morphogenesis hair cell differentiation detection of muscle stretch embryonic skeletal limb joint morphogenesis astrocyte-dopaminergic neuron signaling regulation of cell proliferation regulation of T cell proliferation odontogenesis of dentin-containing tooth embryonic digit morphogenesis regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process skin development cell-cell adhesion mediated by cadherin canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation bone resorption regulation of cell differentiation negative regulation of cell differentiation positive regulation of cell differentiation positive regulation of endothelial cell differentiation regulation of osteoblast differentiation positive regulation of osteoblast differentiation regulation of osteoclast differentiation negative regulation of osteoclast differentiation positive regulation of fibroblast growth factor receptor signaling pathway regulation of angiogenesis positive regulation of angiogenesis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of mitotic cell cycle, embryonic regulation of fibroblast proliferation cell maturation synaptic vesicle transport animal organ development thymus development embryonic organ development oocyte development embryonic foregut morphogenesis positive regulation of skeletal muscle tissue development regulation of smooth muscle cell proliferation neuron fate determination oligodendrocyte differentiation negative regulation of oligodendrocyte differentiation regulation of neurogenesis negative regulation of neurogenesis synapse organization detection of mechanical stimulus smooth muscle cell differentiation myoblast proliferation regulation of timing of anagen regulation of synapse assembly oviduct development canonical Wnt signaling pathway limb development mesenchymal to epithelial transition trachea morphogenesis trachea formation epithelial tube branching involved in lung morphogenesis lung cell differentiation lung-associated mesenchyme development lung epithelial cell differentiation lung induction epithelial cell differentiation involved in prostate gland development epithelial cell proliferation involved in prostate gland development positive regulation of epithelial cell proliferation involved in prostate gland development hair follicle placode formation establishment of blood-brain barrier mesenchymal cell proliferation involved in lung development positive regulation of branching involved in lung morphogenesis endothelial tube morphogenesis fungiform papilla formation sympathetic ganglion development cranial ganglion development regulation of centromeric sister chromatid cohesion cellular response to growth factor stimulus cellular response to indole-3-methanol renal vesicle formation renal inner medulla development renal outer medulla development nephron tubule formation stem cell proliferation regulation of nephron tubule epithelial cell differentiation mesenchymal stem cell differentiation negative regulation of canonical Wnt signaling pathway regulation of calcium ion import acinar cell differentiation synaptic vesicle clustering apoptotic signaling pathway cell-cell adhesion positive regulation of odontoblast differentiation negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway cranial skeletal system development midbrain dopaminergic neuron differentiation positive regulation of blood vessel branching neuron projection extension embryonic brain development dorsal root ganglion development establishment of blood-retinal barrier regulation of protein localization to cell surface positive regulation of determination of dorsal identity positive regulation of neural precursor cell proliferation positive regulation of myoblast proliferation positive regulation of stem cell proliferation negative regulation of apoptotic signaling pathway
          It has to be done as per old AB suggested Products section.

          Disclaimer

          Close

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          guarantee_icon

          性能保障

          只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符,您即可享受免费退换货服务。*

          了解更多
          help_icon

          随时为您服务

          获取常见问题的专家解答,或者直接联系我们的技术专家,咨询应用、设备、常规产品使用问题。

          联系技术支持
          订购 Plus Icon Minus Icon
          • 订单状态查询
          • 订单支持
          • 货号直购
          • 现货供应中心
          • 电子采购
          支持 Plus Icon Minus Icon
          • 帮助&支持
          • 联系我们 - 400 820 8982
          • 技术支持中心
          • 查找文件&证书
          • 报告网站问题
          资源 Plus Icon Minus Icon
          • 学习中心
          • 促销
          • 活动&研讨会
          • 社交媒体
          关于赛默飞 Plus Icon Minus Icon
          • 关于我们
          • 招聘 招聘
          • 投资者关系 投资者关系
          • 新闻 新闻
          • 社会责任 社会责任
          • 商标
          • 政策和通知
          品牌 Plus Icon Minus Icon
          • Thermo Scientific
          • Applied Biosystems
          • Invitrogen
          • Gibco
          • Ion Torrent
          • Unity Lab Services
          • Patheon
          • PPD
          • 服务条款
          • 隐私政策
          • 定价和运输保险政策
          © 2006-2026 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
          China flag icon
          China
          本网站销售的所有产品均不得用于人类或动物之临床诊断或治疗,仅可用于工业或者科研等非医疗目的。
             电子营业执照 | 经营证照公示 | ICP备案号:沪ICP备11003924号 | 沪公网安备 31011502006935号

          Your items have has been added!


          Host server : magellan-search-green-7d94cb4b65-mrft7:80/100.66.76.145:80.
          git-commit: c9e08c96761173abe34e68f880379696776a4827
          git-url: https://github.com/thermofisher/magellan-search
          git-branch: release/2.44.1-2026.02.97.1.0