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Invitrogen
Cathepsin D Recombinant Rabbit Monoclonal Antibody (102)
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Cathepsin D Antibody (MA5-29694) in WB
Western Blot using Cathepsin D Recombinant Rabbit Monoclonal Antibody (102) (Product # MA5-29694) at 1:500 dilution. Lane A: MCF7 Whole Cell Lysate. Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG H&L (DyLight™ 800) at 1:10,000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 45 kDa. Observed band size: 45 kDa. (We are unsure of the identity of these extra bands).
产品信息
MA5-29694
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
102
抗原
Recombinant Mouse Cathepsin D/CTSD Protein (Met1-Leu410)
偶联物
形式
Liquid
浓度
Conc. Not Determined
纯化类型
Protein A
保存液
PBS, pH 6
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Mouse Cathepsin D/CTSD.
靶标信息
Cathepsin D is a gene located on chromosome 11p15.5 that encodes a lysosomal aspartic protease involved in the degradation of proteins. This enzyme is widely expressed in various tissues but is particularly abundant in the liver, kidneys, and brain, where it plays a crucial role in intracellular protein catabolism and turnover. Cathepsin D is synthesized as an inactive precursor, procathepsin D, which is activated in the acidic environment of lysosomes. Beyond its fundamental role in protein degradation, Cathepsin D has been implicated in several physiological and pathological processes, including apoptosis, hormone processing, and antigen presentation. Dysregulation of Cathepsin D expression or activity is associated with various diseases, such as neurodegenerative disorders, cancer, and cardiovascular diseases. In the context of cancer, Cathepsin D overexpression has been linked to tumor progression and metastasis, making it a potential biomarker and therapeutic target. Research continues to explore its diverse biological functions and therapeutic implications in various medical conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cathepsin D; CathepsinD; Ceroid lipofuscinosis neuronal 10; MGC2311; OTTHUMP00000196039; OTTHUMP00000198692
基因别名: CatD; CD; Ctsd
UniProt ID: (Mouse) P18242
Entrez Gene ID: (Mouse) 13033
