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Invitrogen
Cathepsin D Monoclonal Antibody (CTD-19)
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产品信息
MA5-32991
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
CTD-19
抗原
Human liver cathepsin D.
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
保存液
ascites/1.2% sodium acetate with 2mg BSA
内含物
0.01mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 1 mL of PBS to yield a concentration of 100 µg/mL.
Positive Control - WB: human placenta tissue, human A549 whole cell, human PC-3 whole cell, human Hela whole cell, human HepG2 whole cell, human A431 whole cell, human MCF-7 whole cell. IHC: human intestine cancer tissue, human lung cancer tissue, human mammary cancer tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
Cathepsin D is a gene located on chromosome 11p15.5 that encodes a lysosomal aspartic protease involved in the degradation of proteins. This enzyme is widely expressed in various tissues but is particularly abundant in the liver, kidneys, and brain, where it plays a crucial role in intracellular protein catabolism and turnover. Cathepsin D is synthesized as an inactive precursor, procathepsin D, which is activated in the acidic environment of lysosomes. Beyond its fundamental role in protein degradation, Cathepsin D has been implicated in several physiological and pathological processes, including apoptosis, hormone processing, and antigen presentation. Dysregulation of Cathepsin D expression or activity is associated with various diseases, such as neurodegenerative disorders, cancer, and cardiovascular diseases. In the context of cancer, Cathepsin D overexpression has been linked to tumor progression and metastasis, making it a potential biomarker and therapeutic target. Research continues to explore its diverse biological functions and therapeutic implications in various medical conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cathepsin D; CathepsinD; Ceroid lipofuscinosis neuronal 10; ceroid-lipofuscinosis, neuronal 10; epididymis secretory sperm binding protein Li 130P; lysosomal aspartyl peptidase; lysosomal aspartyl protease; MGC2311; OTTHUMP00000196039; OTTHUMP00000198692
基因别名: CLN10; CPSD; CTSD; HEL-S-130P
UniProt ID: (Human) P07339
Entrez Gene ID: (Human) 1509
