Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Cathepsin H/K/L/V Recombinant Rabbit Monoclonal Antibody (JM10-78)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
MA5-32602
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JM10-78
抗原
Synthetic peptide within Human Cathepsin aa 92-138
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: aleurain; Cat H; Cat K; Cat L; Cathepsin B3; Cathepsin BA; Cathepsin K; Cathepsin L1; Cathepsin L2; cathepsin L2, preproprotein; Cathepsin O; cathepsin O1; Cathepsin O2; Cathepsin U; Cathepsin V; Cathepsin X; CP-2; Cyclic protein 2; furless; Major excreted protein; MEP; minisatellite 10q detected by probe MMS10; N-benzoylarginine-beta-naphthylamide hydrolase; nackt; p39 cysteine proteinase; Pro-cathepsin H; Procathepsin L
基因别名: 1190035F06Rik; ACC-4; ACC-5; ACC4; ACC5; AI323530; AL022844; CATHL; catK; CATL; CATL2; CPSB; CTS02; CTSH; CTSK; CTSL; CTSL1; CTSL2; CTSO; CTSO1; CTSO2; CTSU; CTSV; fs; MEP; MMS10-Q; Ms10q; nkt; PKND; PYCD; UNQ268/PRO305
UniProt ID: (Human) P09668, (Human) P43235, (Human) P07711, (Human) O60911, (Rat) P00786, (Mouse) P49935, (Rat) O35186, (Mouse) P55097, (Mouse) P06797, (Rat) P07154
Entrez Gene ID: (Human) 1512, (Human) 1513, (Human) 1514, (Human) 1515, (Rat) 25425, (Mouse) 13036, (Rat) 29175, (Mouse) 13038, (Mouse) 13039, (Rat) 25697
endopeptidase activity
aminopeptidase activity
cysteine-type endopeptidase activity
serine-type endopeptidase activity
protein binding
peptidase activity
cysteine-type peptidase activity
cysteine-type endopeptidase activator activity involved in apoptotic process
HLA-A specific activating MHC class I receptor activity
thyroid hormone binding
fibronectin binding
collagen binding
proteoglycan binding
histone binding
serpin family protein binding
cysteine-type carboxypeptidase activity
kininogen binding
protein complex binding
peptide binding
peptidase activator activity involved in apoptotic process
protein self-association
hydrolase activity
cysteine protease
metanephros development
T cell mediated cytotoxicity
adaptive immune response
immune response-regulating signaling pathway
proteolysis
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of epithelial cell migration
neuropeptide catabolic process
bradykinin catabolic process
positive regulation of peptidase activity
antigen processing and presentation
positive regulation of cell migration
zymogen activation
protein destabilization
response to retinoic acid
membrane protein proteolysis
negative regulation of apoptotic process
surfactant homeostasis
cellular protein metabolic process
positive regulation of angiogenesis
proteolysis involved in cellular protein catabolic process
dichotomous subdivision of terminal units involved in lung branching
ERK1 and ERK2 cascade
cellular response to thyroid hormone stimulus
positive regulation of apoptotic signaling pathway
intramembranous ossification
toll-like receptor signaling pathway
extracellular matrix disassembly
collagen catabolic process
bone resorption
regulation of mitophagy
positive regulation of protein targeting to mitochondrion
antigen processing and presentation of exogenous peptide antigen via MHC class II
macrophage apoptotic process
spermatogenesis
cellular response to starvation
response to glucose
multicellular organism aging
negative regulation of keratinocyte proliferation
protein autoprocessing
nerve development
hair follicle morphogenesis
response to gonadotropin
decidualization
autophagic cell death
response to glucocorticoid
Sertoli cell differentiation
regulation of actin cytoskeleton reorganization
cell communication
protein processing
catagen
epithelial tube branching involved in lung morphogenesis
male gonad development
response to organic cyclic compound
