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Invitrogen
Cbl-b Polyclonal Antibody
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Cbl-b Antibody (PA5-102547) in IHC (P)
Immunohistochemistry analysis of Cbl-b in human kidney cancer and adjacent normal tissues. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Cbl-b polyclonal antibody (Product # PA5-102547) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-102547
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CBLB(Accession Q13191), corresponding to amino acid residues M1-V33.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total CBLB.
靶标信息
This gene encodes a protein of unknown function. The protein contains a bromodomain, a sequence motif often found in transcriptional coactivators, and localizes to the nucleus in testis and several other cell types.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cas-Br-M (murine) ecotropic retroviral transforming sequence b; Casitas B-lineage lymphoma b; casitas B-lineage lymphoma proto-oncogene b; Cbl proto-oncogene B, E3 ubiquitin protein ligase; Cbl proto-oncogene, E3 ubiquitin protein ligase B; E3 ubiquitin protein ligase; RING finger protein 56; RING-type E3 ubiquitin transferase CBL-B; SH3-binding protein CBL-B; signal transduction protein CBL-B; unnamed protein product
基因别名: ADMIO3; Cbl-b; Nbla00127; RNF56
UniProt ID: (Human) Q13191, (Mouse) Q3TTA7, (Rat) Q8K4S7
Entrez Gene ID: (Human) 868, (Mouse) 208650, (Rat) 171136
positive regulation of T cell anergy
immune response
signal transduction
cell surface receptor signaling pathway
protein ubiquitination
regulation of signaling
regulation of cell adhesion
positive regulation of protein ubiquitination
intracellular signal transduction
negative regulation of epidermal growth factor receptor signaling pathway
T cell activation
negative regulation of apoptotic process
positive regulation of protein catabolic process
negative regulation of alpha-beta T cell proliferation
protein stabilization
T cell receptor signaling pathway
regulation of T cell receptor signaling pathway
negative regulation of T cell receptor signaling pathway
negative regulation of T cell activation
protein K63-linked ubiquitination
regulation of postsynaptic neurotransmitter receptor internalization
regulation protein catabolic process at postsynapse
regulation of platelet-derived growth factor receptor-alpha signaling pathway
NLS-bearing protein import into nucleus
response to gravity
response to hormone
cellular response to hydrogen peroxide
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