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Invitrogen
Ceftriaxone Recombinant Mouse Monoclonal Antibody (1E6)
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Ceftriaxone Antibody (MA566587) in SDS-PAGE
SDS-PAGE characterization of Ceftriaxone under reducing conditions. Lane M: Protein marker (kDa); Lane CTX: Purified Ceftriaxone Recombinant Monoclonal (Product # MA566587). Ceftriaxone showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-462.
产品信息
MA566587
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1E6
抗原
Conjugate of CTX hapten and KLH.
偶联物
形式
Liquid
浓度
8.7 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Ceftriaxone is a third-generation cephalosporin antibiotic primarily used to treat bacterial infections in various body locations, including the respiratory tract, skin, soft tissue, and urinary tract. The mechanism of action involves inhibiting bacterial cell wall synthesis by binding to penicillin-binding proteins. Ceftriaxone resistance in Neisseria gonorrhoeae has been linked to mutations in the penA gene, which encodes a penicillin-binding protein, and other genes like ftsX. These mutations can lead to decreased susceptibility to ceftriaxone, impacting its effectiveness. The penA gene is located on the bacterial chromosome and exhibits mosaicism, contributing to the resistance phenotype. The structure of ceftriaxone includes a beta-lactam ring, which is crucial for its antibacterial activity. Understanding the genetic basis of resistance helps in developing strategies to overcome reduced susceptibility and maintain the efficacy of ceftriaxone in clinical settings.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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