Invitrogen

Cerebral Protein 1 Polyclonal Antibody

查看其他8个Cerebral Protein 1抗体

问题与答案

问题与答案

问题与答案

抗体检测数据 (3)

Cerebral Protein 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Cerebral Protein 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 3

Cerebral Protein 1 Antibody (PA5-36441) in IHC (P)

Immunohistochemistry analysis of Cerebral Protein 1 in paraffin-embedded human breast carcinoma tissue. Samples were incubated with Cerebral Protein 1 polyclonal antibody (Product # PA5-36441) at a dilution of 1:100.

Cerebral Protein 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Cerebral Protein 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Cerebral Protein 1 Antibody in Western Blot (WB)

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Cerebral Protein 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of Cerebral Protein 1 in paraffin-embedded human breast carcinoma tissue. Samples were incubated with Cerebral Protein 1 polyclonal antibody (Product # PA5-36441) at a dilution of 1:100.

Cerebral Protein 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of Cerebral 1 in paraffin-embedded human breast carcinoma using Cerebral 1 polyclonal antibody (Product # PA5-36441) at a dilution of 1:100.

Cerebral Protein 1 Antibody in Western Blot (WB) — Western blot analysis of Cerebral 1 using Cerebral 1 polyclonal antibody (Product # PA5-36441) at a dilution of 1:500. Lane 1: Hela cell lysate, Lane 2: sp2/0 cell lysate, Lane 3: H9C2 cell lysate.

Immunogen image

Cerebral Protein 1 Polyclonal Antibody

Immunogen Image Cerebral Protein 1 Polyclonal Antibody

产品信息

PA5-36441

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500

-

免疫组化（石蜡） (IHC (P))

1:50-1:200

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to amino acids 291-340 of human Cerebral 1

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

This antibody detects endogenous protein at a molecular weight of 51 kDa.

Purity is >95% by SDS-PAGE.

靶标信息

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Cerebral protein 1; Cerebral protein 1 homolog; HUCE1; hucep1; Nucleomethylin; Ribosomal RNA-processing protein 8; RRP-8; RRP8 methyltransferase homolog

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基因别名: 1500003O22Rik; 2900001K19Rik; AW538116; hucep-1; KIAA0409; NML; RGD1308302; RRP8

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UniProt ID: (Human) O43159, (Mouse) Q9DB85, (Rat) Q5U4F0

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Entrez Gene ID: (Human) 23378, (Mouse) 101867, (Rat) 308911

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protein binding S-adenosylmethionine-dependent methyltransferase activity methylated histone binding poly(A) RNA binding rRNA (adenine-N6,N6-)-dimethyltransferase activity protein C-terminal carboxyl O-methyltransferase activity tRNA (guanine-N2-)-methyltransferase activity methyltransferase activity C-methyltransferase activity N-methyltransferase activity O-methyltransferase activity S-methyltransferase activity RNA methyltransferase activity mRNA methyltransferase activity tRNA methyltransferase activity protein methyltransferase activity 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity rRNA methyltransferase activity rRNA (uridine-2'-O-)-methyltransferase activity rRNA (adenine-N6-)-methyltransferase activity DNA-methyltransferase activity tRNA (guanine-N1-)-methyltransferase activity rRNA (cytosine-C5-)-methyltransferase activity selenocysteine methyltransferase activity arginine N-methyltransferase activity protein-arginine N-methyltransferase activity lysine N-methyltransferase activity protein-lysine N-methyltransferase activity tRNA (uracil) methyltransferase activity tRNA (guanine) methyltransferase activity tRNA (adenine) methyltransferase activity tRNA (cytosine) methyltransferase activity tRNA (cytosine-5-)-methyltransferase activity tRNA (adenine-N1-)-methyltransferase activity rRNA (adenine) methyltransferase activity rRNA (cytosine) methyltransferase activity rRNA (guanine) methyltransferase activity rRNA (uridine) methyltransferase activity transferase activity protein C-terminal leucine carboxyl O-methyltransferase activity 1-phenanthrol methyltransferase activity protein-arginine N5-methyltransferase activity methylarsonite methyltransferase activity dimethylarsinite methyltransferase activity 4,5-dihydroxybenzo(a)pyrene methyltransferase activity 1-hydroxypyrene methyltransferase activity 1-hydroxy-6-methoxypyrene methyltransferase activity demethylmenaquinone methyltransferase activity cobalt-precorrin-6B C5-methyltransferase activity cobalt-precorrin-7 C15-methyltransferase activity cobalt-precorrin-5B C1-methyltransferase activity cobalt-precorrin-3 C17-methyltransferase activity dimethylamine methyltransferase activity hydroxyneurosporene-O-methyltransferase activity tRNA (adenine-57, 58-N(1)-) methyltransferase activity methylamine-specific methylcobalamin:coenzyme M methyltransferase activity trimethylamine methyltransferase activity methanol-specific methylcobalamin:coenzyme M methyltransferase activity monomethylamine methyltransferase activity P-methyltransferase activity Se-methyltransferase activity 2-phytyl-1,4-naphthoquinone methyltransferase activity tRNA (uracil-2'-O-)-methyltransferase activity tRNA (cytosine-2'-O-)-methyltransferase activity phosphomethylethanolamine N-methyltransferase activity tRNA (cytosine-3-)-methyltransferase activity rRNA (cytosine-2'-O-)-methyltransferase activity rRNA (cytosine-N4-)-methyltransferase activity trihydroxyferuloyl spermidine O-methyltransferase activity

chromatin silencing at rDNA transcription, DNA-templated rRNA processing covalent chromatin modification methylation cellular response to glucose starvation regulation of transcription by glucose positive regulation of cell cycle arrest intrinsic apoptotic signaling pathway by p53 class mediator regulation of transcription, DNA-templated chromatin modification