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Invitrogen
ChREBP Polyclonal Antibody, HRP
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图: 1 / 3
ChREBP Antibody (PA5-22924) in WB
Diabetes 2015 -
Figure 6 ChREBPbeta depletion attenuates glucose-stimulated beta-cell proliferation in INS-1-derived 832/13 cells. A : INS-1-derived 832/13 cells were treated with control siRNAs (siCon) or siRNAs targeted against ChREBPbeta mRNA (Sibeta-01 and -02) and 24 h later cultured for 16 h in 2 or 20 mmol/L glucose. Immunoblotting was performed using antibodies against ChREBP (ChREBPalpha is visualized) and beta-ac... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-22924
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A C-terminal synthetic peptide made to the human CHREBP protein sequence (between residues 800-852).
偶联物
HRP
HRP
HRP
形式
Liquid
浓度
0.86 mg/mL
规格
86 µg
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
4°C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The target sequence has 83% sequence homology with mouse ChREBP.
靶标信息
ChREBP is a transcription factor involved in activating genes that encode enzymes of fatty acid biosynthesis in liver and adipose. This protein may have relevance to lipid metabolism, obesity, and type II diabetes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: bHLH transcription factor; bHLHZip transcription factor; carbohydrate response element binding protein; ChREBP beta; class D basic helix-loop-helix protein 14; Max-like protein; MLX interacting protein-like beta; MLX interactor; putative hepatic transcription factor; unnamed protein product; Williams Beuren syndrome chromosome region 14; Williams-Beuren syndrome chromosomal region 14 protein; Williams-Beuren syndrome chromosome region 14 homolog; Williams-Beuren syndrome chromosome region 14 protein 1; Williams-Beuren syndrome chromosome region 14 protein 2; Williams-Beuren syndrome chromosome region 14 protein 3; WS basic-helix-loop-helix leucine zipper protein
基因别名: bHLHd14; CHREBP; MIO; Mlx; MONDOB; WBSCR14; WS-bHLH
UniProt ID: (Human) Q9NP71, (Rat) Q8VIP2, (Mouse) Q99MZ3
Entrez Gene ID: (Human) 51085, (Rat) 171078, (Mouse) 58805
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
carbohydrate response element binding
protein homodimerization activity
protein heterodimerization activity
protein dimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
DNA-binding transcription factor binding
protein binding
protein kinase binding
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter by glucose
regulation of glycolytic process
regulation of transcription from RNA polymerase II promoter
response to nutrient
positive regulation of cell proliferation
lipid biosynthetic process
response to glucose
glucose mediated signaling pathway
response to nutrient levels
response to vitamin B3
positive regulation of insulin secretion involved in cellular response to glucose stimulus
glucose homeostasis
positive regulation of fatty acid biosynthetic process
positive regulation of glycolytic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of lipid biosynthetic process
fatty acid homeostasis
cellular response to glucose stimulus
negative regulation of oxidative phosphorylation
energy homeostasis
negative regulation of signal transduction by p53 class mediator
regulation of transcription, DNA-templated
anatomical structure morphogenesis
triglyceride homeostasis
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