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Invitrogen
Chlormadinone Acetate Polyclonal Antibody
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产品信息
PA1-75067
产品规格
种属反应
Chemical
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Chlormadinone acetate(3)-BTG
偶联物
形式
Liquid
纯化类型
purified
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Working Concentration: 1.25 µg/mL. Sensitivity: 10 ng/mL Chlormadinone Acetate produces 94% inhibition in a competitive ELISA employing Chlormadinone Acetate polyclonal antibody.
靶标信息
Chlormadinone Acetate is the actetate salt form of chlormadinone, a synthetic progestin with antiandrogenic and antigonadotropic effects. Chlormadinone acetate (CMA) is a potent progesterone receptor (PR) agonist, a partial androgen receptor (AR) antagonist and a weak glucocorticoid receptor (GR) antagonist. Chlormadinone binds to PRs, which induces the expression of progesterone-responsive genes. In addition, chlormadinone blocks ARs in target organs and reduces the activity of skin 5 alpha-reductase; thus inhibiting androgen production and signaling. Through the negative feedback action on the hypothalamus-pituitary system, chlormadinone also suppresses gonadotropin secretion, which prevents ovarian and adrenal androgen production. Therefore, this agent decreases endometrial thickness, increases the viscosity of cervical mucus, inhibits ovulation and suppresses follicular growth and maturation. [National Center for Biotechnology Information. PubChem Compound Database; CID=9324].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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