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Invitrogen
Chromogranin A Recombinant Rabbit Monoclonal Antibody (RM385)
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图: 1 / 12
Chromogranin A Antibody (MA5-33052) in ICC/IF
Immunofluorescence analysis of Chga was performed using 70% confluent log phase SH-SY5Y treated with PTI (1X for 4hrs) cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with Chromogranin A Recombinant Rabbit Monoclonal Antibody (RM385) (Product # MA5-33052) ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-33052
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
RM385
抗原
A peptide corresponding to the N-terminus of human Chromogranin A.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.1 mg/mL
规格
10 µg
纯化类型
Protein A
保存液
PBS with 1% BSA, 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Specificity: reacts to Human Chromogranin A.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: betagranin (N-terminal fragment of chromogranin A); catestatin; CgA; chromofungin; chromogranin A; chromogranin A precursor; Chromogranin-A; CTNNB; DKFZp686D02253; FLJ25606; FLJ37923; MGC105435; parathyroid secretory protein 1; Pituitary secretory protein I; SP-I; unnamed protein product
基因别名: CGA; CHGA; PHE5; PHES
Entrez Gene ID: (Human) 1113
regulation of the force of heart contraction
mast cell chemotaxis
regulation of blood pressure
negative regulation of catecholamine secretion
defense response to bacterium
mast cell degranulation
innate immune response
mast cell activation
negative regulation of insulin secretion
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
positive regulation of cardiac muscle contraction
adenylate cyclase-activating adrenergic receptor signaling pathway
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of relaxation of cardiac muscle
positive regulation of dense core granule biogenesis
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
