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NeoBiotechnologies
Chromogranin A/CHGA (Neuroendocrine Marker) Monoclonal Antibody (LK2H10)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
1113-MSM2-P0
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Pig,
Rat
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
LK2H10
抗原
Human pheochromocytoma
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
200 µg/mL
规格
20 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Does not react with Guinea Pig, Sheep or Rabbit
靶标信息
Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CgA; chromogranin A (parathyroid secretory protein 1); chromogranin A precursor; Chromogranin-A; CTNNB; DKFZp686D02253; FLJ25606; FLJ37923; MGC105435; pancreastatin; Pituitary secretory protein I; SP-I
基因别名: CHGA; ChrA
UniProt ID: (Pig) P04404, (Mouse) P26339
Entrez Gene ID: (Pig) 397540, (Rat) 24258, (Mouse) 12652
regulation of the force of heart contraction
organelle organization
positive regulation of cAMP metabolic process
ovulation cycle
negative regulation of vasodilation
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
negative regulation of neuron death
mast cell chemotaxis
mast cell cytokine production
negative regulation of catecholamine secretion
mast cell degranulation
mast cell activation
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
positive regulation of dense core granule biogenesis
positive regulation of cardiac muscle contraction
adrenergic receptor signaling pathway involved in cardiac muscle relaxation
positive regulation of relaxation of cardiac muscle
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