Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Claudin 17 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
图: 1 / 2
Claudin 17 Antibody (PA5-90256) in IHC (P)
Immunohistochemistry analysis of Claudin 17 in paraffin-embedded mouse kidney. Samples were incubated with Claudin 17 Polyclonal antibody (Product # PA5-90256) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-90256
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human CLDN17 (NP_0362631)
偶联物
形式
Liquid
浓度
1.63 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: CGMKQVQCTG SNERAKAYLL GTSGVLFILT GIFVLIPVSW TANIIIRDFY NPAIHIGQKR ELGAALFLGW ASAAVLFIGG GLLCGFCCCN RKKQGYRYPV PGYRVPHTDK RRNTTMLSKT STSYV; Positive Samples: Mouse kidney, Rat kidney; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, tight junction
靶标信息
Claudin 17 (CLDN17) is a member of the claudin family of proteins, characterized by their involvement in the formation of tight junctions, which are crucial for maintaining the selective permeability barrier in epithelial and endothelial cell layers. CLDN17 is located on chromosome 21q22.11 and encodes a transmembrane protein that contributes to paracellular permeability regulation. This protein is associated with facilitating the passage of ions and small molecules between cells, playing a vital role in maintaining cellular homeostasis and tissue integrity. Recent studies have implicated claudin 17 in tumorigenesis, particularly in hepatocellular carcinoma, where its overexpression is linked to a more malignant phenotype and poor prognosis through mechanisms such as the Tyk2/Stat3 signaling pathway. The dysregulation of claudin 17 and its role in cancer highlight its potential as a biomarker for diagnosis and prognosis, as well as a target for therapeutic interventions aimed at modulating tight junction integrity and cellular interactions in cancerous tissues.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Claudin-17; MGC126552; MGC126554; UNQ758
基因别名: Cldn17
UniProt ID: (Mouse) Q8BXA6
Entrez Gene ID: (Rat) 304125, (Mouse) 239931
