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Invitrogen
Clusterin Alpha Recombinant Rabbit Monoclonal Antibody (5I2Q1)
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Clusterin Alpha Antibody (MA5-51294) in IHC (P)
Immunohistochemistry analysis of Clusterin Alpha in paraffin-embedded human hepatocellular carcinoma. Samples were incubated with Clusterin Alpha Recombinant monoclonal antibody (Product # MA5-51294) using a dilution of 1:70,000 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
产品信息
MA5-51294
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
5I2Q1
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 314-449 of human Clusterin alpha chain (NP_001822.3).
偶联物
形式
Liquid
浓度
0.98 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: STNNPSQAKL RRELDESLQV AERLTRKYNE LLKSYQWKML NTSSLLEQLN EQFNWVSRLA NLTQGEDQYY LRVTTVASHT SDSDVPSGVT EVVVKLFDSD PITVTVPVEV SRKNPKFMET VAEKALQEYR KKHREE
靶标信息
Isoform 1 of Clusterin prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Aging-associated gene 4 protein; aging-associated protein 4; Apo-J; Apolipoprotein J; CLI; Clusterin; Clustrin; Complement cytolysis inhibitor; complement lysis inhibitor; Complement-associated protein SP-40,40; Ku70-binding protein 1; NA1/NA2; SGP-2; Sulfated glycoprotein 2; testosterone repressed prostate message; testosterone repressed prostate message-2; Testosterone-repressed prostate message 2; TRPM-2
基因别名: AAG4; AI893575; APO-J; APOJ; CLI; CLU; CLU1; CLU2; D14Ucla3; KUB1; Msgp-2; NA1/NA2; SGP-2; SGP2; SP-40; Sugp-2; TRPM-2; TRPM2
UniProt ID: (Human) P10909, (Mouse) Q06890
Entrez Gene ID: (Human) 1191, (Mouse) 12759
cell morphogenesis
microglial cell activation
cell death
positive regulation of cell proliferation
protein import
endocrine pancreas development
central nervous system myelin maintenance
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of protein homooligomerization
positive regulation of tumor necrosis factor production
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of nitric oxide biosynthetic process
positive regulation of cell differentiation
neuron projection morphogenesis
protein stabilization
positive regulation of NF-kappaB transcription factor activity
chaperone-mediated protein complex assembly
response to misfolded protein
chaperone-mediated protein folding
microglial cell proliferation
intrinsic apoptotic signaling pathway
regulation of beta-amyloid clearance
regulation of neuron death
positive regulation of neuron death
positive regulation of beta-amyloid formation
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of beta-amyloid formation
regulation of neuronal signal transduction
positive regulation of tau-protein kinase activity
positive regulation of neurofibrillary tangle assembly
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of intrinsic apoptotic signaling pathway
release of cytochrome c from mitochondria
platelet degranulation
lipid metabolic process
complement activation
complement activation, classical pathway
aging
response to light stimulus
response to wounding
response to virus
response to potassium ion
reverse cholesterol transport
estrous cycle
innate immune response
cellular response to growth factor stimulus
