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NeoBiotechnologies
Coagulation Factor VII/F7 Monoclonal Antibody (F7/3515)
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产品信息
2155-MSM5-P1
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2, kappa
分类
Monoclonal
类型
Antibody
克隆号
F7/3515
抗原
Recombinant fragment (around aa 366-466) of human F7 protein
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive Control:Human liver or gastric carcinoma.
Cellular Location: Secreted.
靶标信息
Coagulation factor VII is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in F7 production can cause coagulopathy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Coagulation factor VII; coagulation factor VII (serum prothrombin conversion accelerator); eptacog alfa; Factor 7; Factor7; FVII coagulation protein; preprofactor VIIb; Proconvertin; Serum prothrombin conversion accelerator; SPCA; unnamed protein product
基因别名: F7; SPCA
UniProt ID: (Human) P08709
Entrez Gene ID: (Human) 2155
response to hypoxia
positive regulation of leukocyte chemotaxis
proteolysis
response to stress
blood coagulation
hemostasis
circadian rhythm
response to hormone
response to carbon dioxide
positive regulation of platelet-derived growth factor receptor signaling pathway
protein processing
positive regulation of blood coagulation
positive regulation of cell migration
organ regeneration
response to nutrient levels
positive regulation of TOR signaling
response to estradiol
response to vitamin K
response to genistein
response to estrogen
regulation of body fluid levels
positive regulation of positive chemotaxis
response to growth hormone
response to cholesterol
response to thyroid hormone
response to thyroxine
response to Thyroid stimulating hormone
response to 2,3,7,8-tetrachlorodibenzodioxine
response to astaxanthin
response to thyrotropin-releasing hormone
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