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Invitrogen
Colchicine Recombinant Mouse Monoclonal Antibody (2B4)
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Colchicine Antibody (MA566561) in SDS-PAGE
SDS-PAGE characterization of Colchicine under reducing conditions. Lane M: Protein marker (kDa); Lane CCC: Purified Colchicine Recombinant Monoclonal (Product # MA566561). Colchicine showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-271.
产品信息
MA566561
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2B4
抗原
Conjugate of CCC hapten and KLH.
偶联物
形式
Liquid
浓度
7.9 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Colchicine is a naturally occurring alkaloid derived from the plant Colchicum autumnale, known for its potent anti-inflammatory properties and its ability to inhibit microtubule polymerization. It is primarily used in the treatment of gout, Behcet's disease, and familial Mediterranean fever. The biosynthesis of colchicine involves a complex pathway that has been elucidated through transcriptomics and metabolic logic, despite the absence of a sequenced genome or genetic tools in its native host. Structurally, colchicine is characterized by its unique tropolone ring, which is crucial for its biological activity. Recent research has focused on synthesizing colchicine derivatives to enhance its therapeutic potential and reduce toxicity, which is a significant concern due to its narrow therapeutic index. These derivatives are being explored for their efficacy in cancer treatment, leveraging colchicine's ability to disrupt cell division. Synonyms for colchicine include (-)-colchicine, Colchicum alkaloid, anti-microtubulin agent, gout medication, anti-inflammatory drug, microtubule inhibitor, tropolone alkaloid, and colchicine derivative.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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