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Invitrogen
Complement C4 Polyclonal Antibody
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产品信息
PA5-143803
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ Ig
分类
Polyclonal
类型
Antibody
抗原
The polyclonal antibody reacts with Rat C4
偶联物
形式
Liquid
浓度
100 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 0.1% BSA
内含物
0.02% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: c4 complement; Complement C4; complement C4-like protein; complement component 4 (within H-2S); complement component 4, gene 1; complement component 4, gene 2; complement component 4B (Chido blood group); complement component 4B (Childo blood group); DADB-112B14.11; DAMC-258G8.6; FLJ60561; MGC164979
基因别名: C4; C4-1; C4-2; C4a; C4b; C4l
UniProt ID: (Rat) P08649
Entrez Gene ID: (Rat) 24233, (Rat) 406161
inflammatory response
complement activation
complement activation, classical pathway
negative regulation of endopeptidase activity
innate immune response
positive regulation of apoptotic cell clearance
biological_process
immunoglobulin mediated immune response
detection of molecule of bacterial origin
