Invitrogen

Complement C5b-9 Monoclonal Antibody (3R2/0)

Name: Complement C5b-9 Monoclonal Antibody (3R2\/0)
Brand: Invitrogen
SKU: MA5-28502

1 篇参考文献

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

产品信息

MA5-28502

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

免疫组化（冰冻） (IHC (F))

Assay-dependent

流式细胞分析 (Flow)

Assay-dependent

酶联免疫吸附实验 (ELISA)

Assay-dependent

亲和纯化 (AP)

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产品规格

种属反应

Human

已发表种属

C. elegans

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

3R2/0

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.093 mg/mL

纯化类型

Protein A

保存液

BBS

内含物

<0.1% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2745462

产品详细信息

This antibody recognizes the SC5b-9 complex of around 330 kDa. Both the classical and alternative complement pathways result in the formation of the cytolysis inducing C5b-9 complex.

靶标信息

The complement system is a fundamental part of innate immunity, consisting of over 45 genes that encode various complement components, regulators, and receptors. The complement C5b-9 complex, also known as the Membrane Attack Complex (MAC), plays a crucial role in the immune defense mechanism. It includes the sequential assembly of proteins C5b, C6, C7, C8, and multiple copies of C9. This complex forms transmembrane channels that puncture the cell membrane of target cells, leading to cell lysis. Specifically, MAC has significant implications in mediating cell death in both pathogenic organisms and cancer cells. The genes involved are clustered across the human genome, mainly organized in three significant loci. The understanding of the C5b-9 complex's function extends beyond its antimicrobial roles to include its interactions with tumor cells, where it can induce cell death and influence cancer progression.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C5a anaphylatoxin; C5b-9; Complement C5; Complement component C6; Complement component C7; Complement component C9; MAC Complex; Membrane Attack Complex; prepro-C5

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基因别名: ARMD15; C5; C5a; C5b; C5D; C6; C7; C9; C9D; CPAMD4; ECLZB