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Invitrogen
Connexin 31.1 Polyclonal Antibody
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Connexin 31.1 Antibody (PA5-103852) in ICC/IF
Immunocytochemistry analysis of Connexin 31.1 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Connexin 31.1 polyclonal antibody (Product # PA5-103852) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 conjugate... View More
产品信息
PA5-103852
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human GJB5(Accession O95377), corresponding to amino acid residues G233-L273.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total GJB5.
靶标信息
The connexin family of proteins form hexameric complexes, called connexons, that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane α-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino acid substitutions in the most highly conserved domains; the transmembrane and extracellular regions. Connexin 31.1, Cx31.1 or Gap junction beta-5 protein, is a 271 amino acid protein that is predominantly expressed in skin with lower expression in testis. Expression of connexin 31.1 is required for normal placental development in mice. Down-regulation of the connexin 31.1 gene correlates with head and neck squamous cell carcinomas (HNSCC) and therefore it may be a potential therapeutic target.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: connexin 31.1; Connexin-31.1; Cx31.1; Gap junction beta-5 protein; gap junction membrane channel protein beta 5; gap junction protein, beta 5 (connexin 31.1); gap junction protein, beta 5, 31.1kDa; gap junctional protein cx31.1
基因别名: Cnx31.1; CX31.1; Cxn-31.1; Gjb-5; GJB5
UniProt ID: (Human) O95377, (Mouse) Q02739, (Rat) P28232
Entrez Gene ID: (Human) 2709, (Mouse) 14622, (Rat) 29586
