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Invitrogen
Cripto Polyclonal Antibody
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产品信息
PA5-34476
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 17 amino acid peptide near the amino terminus of human TDGF1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A suggested positive control is 293 cell lysate.
PA5-34476 can be used with blocking peptide PEP-1518.
靶标信息
Cripto (TDGF1) is a GPI-anchored cell membrane proetin involved in Nodal signaling. Cell associated TDGF1 acts as a a Nodeal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulated Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. TDGF1 is expressed both in ES cells and during the early phases of embryo development, while in adults it is reactivated in a wide range of epithelial cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CRGF; Cripto growth factor; Cripto, EGF-CFC family member; Cripto-1; Cripto-1 growth factor; Cripto-3; Epidermal growth factor-like Cripto protein; Epidermal growth factor-like cripto protein CR1; Protein Cripto; TDGF2; Teratocarcinoma-derived growth factor; Teratocarcinoma-derived growth factor 1; TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR)
基因别名: CR; CR1; CRGF; CRIPTO; CRIPTO-1; TDGF1
UniProt ID: (Human) P13385, (Mouse) P51865
Entrez Gene ID: (Human) 6997, (Rat) 680246, (Mouse) 21667
activation of MAPK activity
morphogenesis of a branching structure
cell migration involved in sprouting angiogenesis
epidermal growth factor receptor signaling pathway
heart development
positive regulation of cell proliferation
anterior/posterior axis specification, embryo
embryo development
regulation of signal transduction
positive regulation of endothelial cell migration
peptidyl-serine phosphorylation
cell differentiation
positive regulation of cell migration
mammary gland development
somatic stem cell population maintenance
cellular response to hepatocyte growth factor stimulus
negative regulation of apoptotic process
cellular response to fibroblast growth factor stimulus
positive regulation of peptidyl-tyrosine phosphorylation
cellular response to interferon-gamma
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
vasculogenesis
in utero embryonic development
positive regulation of cell-matrix adhesion
gastrulation
anterior/posterior axis specification
regulation of cell migration
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
nodal signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
cardiac muscle cell differentiation
canonical Wnt signaling pathway
