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Invitrogen
Cripto Monoclonal Antibody (237603)
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产品信息
MA5-61000
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
237603
抗原
Mouse myeloma cell line NS0-derived recombinant mouse Cripto, Arg26-Gln150
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
Cripto (TDGF1) is a GPI-anchored cell membrane proetin involved in Nodal signaling. Cell associated TDGF1 acts as a a Nodeal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulated Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. TDGF1 is expressed both in ES cells and during the early phases of embryo development, while in adults it is reactivated in a wide range of epithelial cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cripto growth factor; Cripto-1; Cripto-3; Epidermal growth factor-like Cripto protein; TDGF2; Teratocarcinoma-derived growth factor; TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR)
基因别名: CR1; Cripto; Tdgf1
UniProt ID: (Mouse) P51865
Entrez Gene ID: (Mouse) 21667
activation of MAPK activity
vasculogenesis
in utero embryonic development
morphogenesis of a branching structure
positive regulation of cell-matrix adhesion
cell migration involved in sprouting angiogenesis
epidermal growth factor receptor signaling pathway
gastrulation
heart development
positive regulation of cell proliferation
anterior/posterior axis specification, embryo
anterior/posterior axis specification
regulation of signal transduction
positive regulation of endothelial cell migration
peptidyl-serine phosphorylation
cell differentiation
regulation of cell migration
positive regulation of cell migration
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
cellular response to hepatocyte growth factor stimulus
nodal signaling pathway
negative regulation of apoptotic process
cellular response to fibroblast growth factor stimulus
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
positive regulation of peptidyl-tyrosine phosphorylation
cardiac muscle cell differentiation
canonical Wnt signaling pathway
cellular response to interferon-gamma
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
