Invitrogen

Crk Polyclonal Antibody

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
Crk Polyclonal Antibody

产品信息

PA5-116651

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 1-304 of human CRK/CRKII (NP_0584312)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.18 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2901282

产品详细信息

Positive Samples: A-549, MCF7, BT-474, Mouse brain

Immunogen sequence: MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS VSENSRVSHY IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL LEFYKIHYLD TTTLIEPVSR SRQGSGVILR QEEAEYVRAL FDFNGNDEED LPFKKGDILR IRDKPEEQWW NAEDSEGKRG MIPVPYVEKY RPASASVSAL IGGNQEGSHP QPLGGPEPGP YAQPSVNTPL PNLQNGPIYA RVIQKRVPNA YDKTALALEV GELVKVTKIN VSGQWEGECN GKRGHFPFTH VRLLDQQNPD EDFS

靶标信息

The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Adapter molecule crk; avian sarcoma virus CT10 (v-crk) oncogene homolog; CRK1; CSAID-binding protein; Csaids binding protein; CT-10 related kinase 3; cytokine suppressive anti-inflammatory drug binding protein; cytokine suppressive anti-inflammatory drug binding protein 1; Cytokine suppressive anti-inflammatory drug-binding protein; MAP kinase 14; MAP kinase MXI2; MAP kinase p38 alpha; MAPK 14; MAX-interacting protein 2; mitogen activated protein kinase 14; Mitogen-activated protein kinase 14; Mitogen-activated protein kinase p38 alpha; p38; p38 alpha; p38 MAP kinase; p38 MAP kinase alpha; p38 MAPK; p38 mitogen activated protein kinase; p38alpha Exip; Proto-oncogene c-Crk; SAPK2a; Stress-activated protein kinase 2a; tRNA synthetase cofactor p38; v-crk avian sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene-like protein

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基因别名: c-Crk; CRK; Crk-I; Crk-II; Crk-III; Crk1; Crk3; CRKII; CrkIII; Crko; CSBP; CSBP1; CSBP2; CSPB1; EXIP; MAPK14; MXI2; p38; p38-alpha; p38a; p38ALPHA; p38MAPK; PRKM14; PRKM15; RK; SAPK2A

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UniProt ID: (Human) P46108, (Mouse) Q64010, (Human) Q16539, (Mouse) P47811

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Entrez Gene ID: (Human) 1398, (Mouse) 12928, (Human) 1432, (Mouse) 26416

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功能
SH3/SH2 adaptor activity protein binding SH2 domain binding protein phosphorylated amino acid binding ephrin receptor binding protein domain specific binding protein binding, bridging protein serine/threonine kinase activity MAP kinase activity MAP kinase kinase activity ATP binding protein C-terminus binding enzyme binding protein phosphatase binding NFAT protein binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups scaffold/adaptor protein non-receptor serine/threonine protein kinase
参与通路
activation of MAPKK activity regulation of transcription from RNA polymerase II promoter regulation of actin cytoskeleton organization regulation of Rac protein signal transduction Fc-gamma receptor signaling pathway involved in phagocytosis regulation of GTPase activity vascular endothelial growth factor receptor signaling pathway ephrin receptor signaling pathway positive regulation of substrate adhesion-dependent cell spreading positive regulation of signal transduction DNA damage checkpoint activation of MAPK activity cell morphogenesis cartilage condensation angiogenesis placenta development chondrocyte differentiation glucose metabolic process transcription, DNA-templated apoptotic process movement of cell or subcellular component chemotaxis signal transduction cell surface receptor signaling pathway transmembrane receptor protein serine/threonine kinase signaling pathway Ras protein signal transduction skeletal muscle tissue development response to glucose positive regulation of gene expression positive regulation of myotube differentiation myoblast differentiation involved in skeletal muscle regeneration peptidyl-serine phosphorylation fatty acid oxidation osteoclast differentiation positive regulation of cyclase activity lipopolysaccharide-mediated signaling pathway response to muramyl dipeptide intracellular signal transduction cellular response to vascular endothelial growth factor stimulus response to muscle stretch p38MAPK cascade positive regulation of protein import into nucleus signal transduction in response to DNA damage positive regulation of blood vessel endothelial cell migration positive regulation of erythrocyte differentiation positive regulation of myoblast differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of glucose import protein autophosphorylation regulation of sequence-specific DNA binding transcription factor activity striated muscle cell differentiation positive regulation of muscle cell differentiation positive regulation of cardiac muscle cell proliferation 3'-UTR-mediated mRNA stabilization cellular response to lipopolysaccharide cellular response to ionizing radiation negative regulation of canonical Wnt signaling pathway positive regulation of brown fat cell differentiation stress-induced premature senescence cellular response to virus regulation of cytokine production involved in inflammatory response positive regulation of myoblast fusion regulation of signal transduction by p53 class mediator positive regulation of reactive oxygen species metabolic process positive regulation of interleukin-12 secretion regulation of transcription, DNA-templated protein phosphorylation cellular response to DNA damage stimulus phosphorylation response to lipopolysaccharide stress-activated MAPK cascade
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