Invitrogen

CrkL Monoclonal Antibody (5E12)

Name: CrkL Monoclonal Antibody (5E12)
Brand: Invitrogen
SKU: MA5-15867

查看其他31个CrkL抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (2)

图: 1 / 2

CrkL Antibody (MA5-15867) in WB

Western blot analysis of CRKL using a CRKL monoclonal antibody (Product # MA5-15867) against a human CRKL (AA: 100-303) recombinant protein.

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产品信息

MA5-15867

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

流式细胞分析 (Flow)

1:200-1:400

酶联免疫吸附实验 (ELISA)

1:10,000

产品规格

种属反应

Human, Mouse

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

5E12

抗原

Purified recombinant fragment of human CRKL expressed in E. Coli.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

Conc. Not Determined

保存液

ascites

内含物

0.03% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_11153568

产品详细信息

MA5-15867 targets CRKL in indirect ELISA, FACS and WB applications and shows reactivity with Human samples.

The MA5-15867 immunogen is purified recombinant fragment of human CRKL expressed in E. Coli. .

MA5-15867 detects CRKL which has a predicted molecular weight of approximately 39kDa.

靶标信息

The CRKL gene encodes the CRK-like protein, an adaptor protein that plays a crucial role in intracellular signaling pathways related to cell proliferation, differentiation, and migration. CRKL contains SH2 and SH3 domains that facilitate interactions with other signaling molecules, influencing multiple pathways such as the MAPK, PI3K, and STAT pathways. It is involved in processes like cytoskeleton reorganization and immune cell signaling, with significant implications for development and cancer. CRKL is notably associated with Philadelphia chromosome-positive leukemias, where it interacts with the BCR-ABL fusion protein, contributing to leukemogenesis. Additionally, dysregulation of CRKL can affect cardiovascular development, leading to congenital heart defects. Research into CRKL focuses on understanding its role in signal transduction and its potential as a therapeutic target due to its involvement in oncogenic and developmental pathways.

仅用于科研。不用于诊断过程。未经明确授权不得转售。