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Bethyl Laboratories
Cyclin C Polyclonal Antibody
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产品信息
IHC-00592
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 233 and 283 of human cyclin C.
偶联物
形式
Liquid
浓度
0.10 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Chicken, Turkey, Bovine, Dog, Horse, Rabbit, Guinea pig_10141, Pig, Panda, Orangutan, Monkey, Gorilla and Chimpanzee
靶标信息
Cyclin C was originally identified by a genetic screen for human and Drosophila cDNAs that complement a triple knock out of the CLN genes in Saccharomyces cerevisiae. Cyclin C is a nuclear protein present in a multiprotein complex. It interacts both in vitro and in vivo with cdk 8, a novel protein kinase of the cdk family. It is suggested that cyclin C and cdk 8 control RNA polymerase II function. Human cdk 8 cyclin C might be functionally associated with the mammalian transcription apparatus, perhaps involved in relaying growth regulatory signals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cyclin-C; hSRB11; SRB11 homolog
基因别名: CCNC; CycC
UniProt ID: (Human) P24863
Entrez Gene ID: (Human) 892
transcription initiation from RNA polymerase II promoter
protein phosphorylation
protein ubiquitination
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of transcription from RNA polymerase II promoter
negative regulation of triglyceride metabolic process
positive regulation of phosphorylation of RNA polymerase II C-terminal domain
