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Invitrogen
Cyclin H Polyclonal Antibody
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Product Details
PA5-17586
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues near the carboxy-terminus of cyclin H
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with other family members at physiological levels.
Target Information
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAK complex subunit; CDK-activating kinase complex subunit; cyclin-dependent kinase-activating kinase complex subunit; Cyclin-H; MO15-associated protein; OTTHUMP00000222395; OTTHUMP00000222396; p34; p37
Gene Aliases: 6330408H09Rik; AI661354; AV102684; AW538719; CAK; CCNH; CycH; p34; p37
UniProt ID: (Human) P51946, (Mouse) Q61458, (Rat) Q9R1A0
Entrez Gene ID: (Human) 902, (Mouse) 66671, (Rat) 84389
protein binding
DNA-dependent ATPase activity
RNA polymerase II carboxy-terminal domain kinase activity
cyclin-dependent protein serine/threonine kinase regulator activity
cyclin-dependent protein serine/threonine kinase activity
kinase activity
protein kinase binding
molecular_function
kinase activator
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
transcription-coupled nucleotide-excision repair
nucleotide-excision repair, preincision complex assembly
transcription initiation from RNA polymerase I promoter
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
7-methylguanosine mRNA capping
protein phosphorylation
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of phosphorylation of RNA polymerase II C-terminal domain
regulation of cyclin-dependent protein serine/threonine kinase activity
transcription, DNA-templated
regulation of transcription, DNA-templated
cell cycle
phosphorylation
regulation of cell cycle
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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