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Invitrogen
Cyclophilin B Monoclonal Antibody (M019)
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Cyclophilin B Antibody (MA5-47662) in ICC/IF
Immunocytochemistry analysis of Cyclophilin B in methanol: acetone (1:1) fixed human A549 lung cancer cells. The cells were labeled with mouse Cyclophilin B monoclonal antibody (Product # MA5-47662). The antibody was detected using goat anti-mouse DyLight® 594.
产品信息
MA5-47662
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
M019
抗原
Clone M019 was generated from a proprietary antigen related to cyclophilin B from the MCF7 breast cancer cell line.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein G
保存液
PBS with 1mg/mL BSA, 50% glycerol
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Clone M019 detects a 20 kDa* band corresponding to the molecular mass of cyclophilin B on SDS-PAGE immunoblots of human LNCaP, MeWo, MCF7, and MDA-MB-231 cell lysates, as well as full length recombinant cyclophilin B, but does not detect recombinant cyclophilin A. The antibody can be used for western blot, immunoprecipitation, protein ELISA, and immunocytochemistry.
靶标信息
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cyclophilin B; cyclophilin-like protein; Cyp B; CYP-S1; EC 5.2.1.8; epididymis secretory protein Li 39; Peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B (cyclophilin B); PPIase; PPIase B; Rotamase; Rotamase B; S-cyclophilin; SCYLP
基因别名: CYP-S1; CYPB; HEL-S-39; OI9; PPIB; SCYLP
UniProt ID: (Human) P23284
Entrez Gene ID: (Human) 5479
protein peptidyl-prolyl isomerization
positive regulation of multicellular organism growth
positive regulation by host of viral process
positive regulation by host of viral genome replication
protein stabilization
bone development
chaperone-mediated protein folding
regulation of post-translational protein modification
