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Invitrogen
Cyclopiazonic acid Recombinant Mouse Monoclonal Antibody (1C10)
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Cyclopiazonic acid Antibody (MA566560) in SDS-PAGE
SDS-PAGE characterization of Cyclopiazonic acid under reducing conditions. Lane M: Protein marker (kDa); Lane CPA: Purified Cyclopiazonic acid Recombinant Monoclonal (Product # MA566560). Cyclopiazonic acid showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-359.
产品信息
MA566560
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1C10
抗原
Conjugate of CPA hapten and KLH.
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Cyclopiazonic acid (CPA) is a toxic indole tetramic acid produced by fungi such as Aspergillus and Penicillium species. It is known for its ability to inhibit calcium-dependent ATPases, specifically targeting the sarcoendoplasmic reticulum Ca2+-ATPase (SERCA), which disrupts calcium homeostasis within cells. This inhibition can lead to various toxic effects, including weight loss, muscle degeneration, convulsions, and potentially death in animals. CPA has been detected in various foods and feeds, posing a risk of acute mycotoxicoses in humans, with symptoms such as giddiness and nausea. Additionally, CPA has shown promising antiplasmoidal activities, comparable to chloroquine, and has been identified as an inhibitor of respiratory syncytial virus (RSV) in cell-based assays. Its neurotoxic effects have been studied in animal models, indicating potential depressive symptoms and neurocognitive impairments.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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