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Invitrogen
Cytochrome C Polyclonal Antibody
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产品信息
PA5-28856
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Fruit fly,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Full length human Cytochrome C Recombinant protein.
偶联物
形式
Liquid
浓度
0.18 mg/mL
规格
18 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol, 1% BSA
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: 293T, K562, THP-1, HL-60, Mouse brain, PC-12, CYCS shRNA-transfected 293T, 293T, SCC-25.
Predicted reactivity: Mouse (91%), Rat (91%), Xenopus laevis (85%), Dog (89%), Pig (90%), Chicken (87%), Chimpanzee (100%), Bovine (90%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in oxidative phosphorylation and the production of cellular ATP. Release of cytochrome C from the mitochondria to the cytosol is triggered by apoptotic stimuli. In the cytoplasm, the cytochrome C binds apoptotic protease activating factor which activates the apoptotic initiator procaspase 9. Cytosolic cytochrome C functions in the activation of caspase 3, an ICE family molecule that is a key effector of apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: APOCYTOCHROME C-A; AT1G22840; AT4G10040; ATCYTC-A; CG17903-PA; CG17903-PB; CRF; CYCS; Cyt-c-p-PA; Cyt-c-p-PB; CYTC-1; CYTC-2; Cytochrome c; cytochrome c DC4; Cytochrome C, expressed in somatic tissues; Cytochrome c, somatic; CYTOCHROME C-1; CYTOCHROME C-2; CYTOCHROME C-A; Cytochrome c-proximal; cytochrome-c-p; Cytochrome-c-proximal; F19G10.20; F19G10_20; hc1; lethal (2) k13905; RH17228p; T5L19.170; T5L19_170; unnamed protein product
基因别名: CG17903; CYC; CYC2; CYCS; CYCSA; Cyct-c-p; Cyt C; cyt c-p; Cyt-c; Cyt-c-p; Cyt-c2; cyt.c; CytC; CytC-2; Cytc-p; CYTC2; cytochrome c; DC4; dCyt.C-p; DMc01; Dmel\CG17903; Dmel_CG17903; HCS; l(2)k13905; pDMc01; THC4
UniProt ID: (Dog) P00011, (Human) P99999, (Mouse) P62897, (Rat) P62898, (Fruit fly) P84029
Entrez Gene ID: (Dog) 475258, (Human) 54205, (Mouse) 13063, (Rat) 25309, (Fruit fly) 34996
apoptotic process
mitochondrial electron transport, ubiquinol to cytochrome c
mitochondrial electron transport, cytochrome c to oxygen
cellular respiration
apoptotic signaling pathway
intrinsic apoptotic signaling pathway
execution phase of apoptosis
apoptotic DNA fragmentation
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
hydrogen peroxide metabolic process
ATP synthesis coupled electron transport
oxidative phosphorylation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
oxidation-reduction process
response to ischemia
response to oxidative stress
negative regulation of hydrogen peroxide biosynthetic process
glial cell apoptotic process
positive regulation of cellular respiration
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