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Invitrogen
Cytochrome C Polyclonal Antibody
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Cytochrome C Antibody (PA5-79119) in IHC (P)
Immunohistochemistry (Paraffin) analysis of Cytochrome C in paraffin-embedded section of mouse brain tissue using Cytochrome C Polyclonal Antibody (Product # PA5-79119). Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution ) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with the primary antibody at a 1 µg/mL... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-79119
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived mouse Cytochrome C recombinant protein (Position: G2-E105).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human HL-60 whole cell, human K562 whole cell, human U-937 whole cell, human U20S whole cell, human T-47D whole cell, human PC-3 whole cell, human CACO-2 whole cell, rat brain tissue, rat heart tissue, rat kidney tissue, rat C6 whole cell, mouse brain tissue, mouse heart tissue, mouse kidney tissue, mouse Neuro-2a whole cell. IHC: mouse brain tissue, mouse intestine tissue, rat brain tissue, rat intestine tissue.
靶标信息
Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in oxidative phosphorylation and the production of cellular ATP. Release of cytochrome C from the mitochondria to the cytosol is triggered by apoptotic stimuli. In the cytoplasm, the cytochrome C binds apoptotic protease activating factor which activates the apoptotic initiator procaspase 9. Cytosolic cytochrome C functions in the activation of caspase 3, an ICE family molecule that is a key effector of apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: APOCYTOCHROME C-A; AT1G22840; AT4G10040; ATCYTC-A; CRF; CYTC-1; CYTC-2; Cytochrome c; Cytochrome C, expressed in somatic tissues; Cytochrome c, somatic; CYTOCHROME C-1; CYTOCHROME C-2; CYTOCHROME C-A; F19G10.20; F19G10_20; hc1; T5L19.170; T5L19_170
基因别名: CYC; CYCS; CYCSA
UniProt ID: (Mouse) P62897, (Rat) P62898
Entrez Gene ID: (Mouse) 13063, (Rat) 25309
mitochondrial electron transport, ubiquinol to cytochrome c
mitochondrial electron transport, cytochrome c to oxygen
apoptotic DNA fragmentation
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
hydrogen peroxide metabolic process
ATP synthesis coupled electron transport
response to ischemia
response to oxidative stress
negative regulation of hydrogen peroxide biosynthetic process
glial cell apoptotic process
positive regulation of cellular respiration
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
