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Invitrogen
Cytohesin 3 Polyclonal Antibody
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Cytohesin 3 Antibody (PA5-75368) in WB
Western blot analysis of Cytohesin 3 in Lane 1: 3T3-L1 whole cell lysate (40 µg), Lane 2: H9C2 whole cell lysate (40 µg), Lane 3: A2780 whole cell lysate (40 µg), Lane 4: H1792 whole cell lysate (40 µg), Lane 5: A375 whole cell lysate (20 µg). Samples were incubated with Cytohesin 3 polyclonal antibody (Product # PA5-75368) at a dilution of 1:2000.
产品信息
PA5-75368
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 371-400 of Human GRP1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
GRP1 (general receptor for phosphoinositides-1) contains a Pleckstrin homology (PH) domain as well as a Sec7 domain. The PH domain has high binding affinity for phosphatidylinositol 3,4,5-trisphosphate Ptdlns(3,4,5)P3), while the Sec7 homology domain is responsible for catalyzing guanine nucleotide exchange of ADP-ribosylation factor (ARF) proteins. GRP1 co-localizes with ARF6 and catalyzes GTP/GDP exchange on ARF6. It is known to interact with Ptdlns(3,4,5)P3 localized to the plasma membrane in vitro and may also be a Ptdlns(3,4,5)P3 receptor. Additionally, GRP1 may regulate protein sorting and membrane trafficking through interaction with the guanosine triphosphate ARF, and may control cell adhesion through interaction with integrins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ARF nucleotide-binding site opener 3; CLM3; Cytohesin-3; General receptor of phosphoinositides 1; Grp1; mSec7-3; PH, SEC7 and coiled-coil domain-containing protein 3; pleckstrin homology, Sec7 and coiled-coil domains 3; pleckstrin homology, Sec7 and coiled/coil domains 3; Protein ARNO3; rSec7-3; SEC7 homolog C
基因别名: AI648983; ARNO3; CLM3; CYTH3; GRP1; PSCD3; Sec7; Sec7C
UniProt ID: (Human) O43739, (Mouse) O08967
Entrez Gene ID: (Human) 9265, (Rat) 116693, (Mouse) 19159
