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Invitrogen
Cytokeratin 10/13 Monoclonal Antibody (EBS-IF-003)
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产品信息
MA5-33317
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Cat,
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
EBS-IF-003
抗原
Cytoskeleton preparation from HeLa cells
偶联物
形式
Liquid
浓度
100 µg/mL
纯化类型
purified
保存液
PBS
内含物
0.02% sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
EBS-IF-003 reacts with 53kDa (CK13) and 56.6kDa (CK10) cytokeratin proteins as indicated by immunoblotting. On formalin-fixed, paraffin-embedded tissue sections EBS-IF-003 recognizes only CK13. On cryostat sections EBS-IF-003 serves as differentiation-related marker of all stratified epithelia; it stains all suprabasal cells in both cornifying and noncornifying stratified epithelia and more differentiated cells of squamous carcinomas. In paraffin sections EBS-IF-003 does not stain CK10 positive, CK13 negative epithelia, as for example epidermis.
靶标信息
Cytokeratins(CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie. Skin) and non-keratinizing cells (ie. Mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different CKs in the molecular range of 40-70 k Da and isoelectric points of 5-805 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CK-10; CK-13; cytokeratin 10; cytokeratin 13; Cytokeratin-10; Cytokeratin-13; epithelial keratin 10; Epithelial keratin-10; K10; K13; keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris); keratin 10, type I; keratin 13, type I; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 13; Keratin-10; Keratin-13
基因别名: BCIE; BIE; CK-10; CK10; CK13; EHK; K10; K13; KER10; KPP; KRT10; KRT13; WSN2
UniProt ID: (Human) P13645, (Dog) Q6EIZ0, (Human) P13646
Entrez Gene ID: (Human) 3858, (Dog) 491006, (Dog) 490983, (Human) 3860
